RG 14620

Research use only, not for human use.

RG14620 is an epidermal growth factor receptor (EGFR) inhibitor.

RG-14620 is an EGFR inhibitor. It is a non-phenolic tyrphostin analog, which is selective for the EGF receptor and long acting. It inhibits EGF-stimulated HER14 cell proliferation (IC50=3 μM) as well as tumor growth in vivo.

RG14620 inhibits colony formation (IC50=3 μM) and DNA synthesis (IC50=1 μM) by HER 14 cells, which are stimulated by 50 ng/mL EGF, in a dose-dependent manner. RG14620 also suppresses colony formation(IC50=4 μM) and DNA synthesis (IC50=1.25 μM) by EGF-stimulated MH-85 cells in a dose-dependent manner. The growth-inhibitory effect of RG14620 irreversible.

RG14620, at a dose of 200 g/mouse/day inhibits H-85 tumor growth in nude mice. Mice show less cachexia and hypercalcemia, eat more food, and are more active than untreated MH-85 tumor-bearing animals.

RG 14620 | TYRPHOSTIN RG 14620.

Others

Other Targets

HER14 colony formation| HER14 DNA synthesis

Cancer

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136831-49-7

275.13

C14H8Cl2N2

>98% (HPLC)

DMSO : ≥ 26 mg/mL; 94.50 mM

c1cc(cnc1)/C(=C\c1cc(cc(c1)Cl)Cl)/C#N

(E)-3-(3,5-dichlorophenyl)-2-(pyridin-3-yl)acrylonitrile

(-20℃)

With Ice Pack

≥ 2 years