(-)-MK 801 Maleate( (-)-MK 801 (Maleate) )

Catalog No. M17887 CAS No. 121917-57-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

(-)-MK 801 Maleate
Note

Research use only, not for human use.
Brief Description

MK-801 is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.
Description

MK-801 is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.
In Vitro

(-)-Dizocilpine maleate ((-)-MK-801 maleate) significantly inhibited the uptake of all three (norepinephrine, dopamine and serotonin) monoamine transporters in a dose-dependent manner in HEK cells. The Ki values of (-)-Dizocilpine on the norepinephrine, dopamine and serotonin transporters are 3.7 μM, 40 μM and 47 μM, respectively.
In Vivo

(-)-Dizocilpine maleate (0.1 mg/kg; intraperitoneal injection; male adult C57BL/6 mice) treatment induces rapid antidepressant effects in the social defeat stress model. Animal Model:Male adult C57BL/6 mice ( 20-25g; aged 8 weeks) with social defeat stress model Dosage:0.1 mg/kg Administration:Intraperitoneal injection Result:Induced rapid antidepressant effects in the social defeat stress model.
Synonyms

(-)-MK 801 (Maleate)
Pathway

Others
Target

Other Targets
Recptor

NMDA Receptor
Research Area

Neurological Disease
Indication

——

1.Wong EH, et al. Proc Natl Acad Sci U S A, 1986, 83(18), 7104-7108.

Calculator

molnova catalog