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(-)-MK 801 Maleate
CAS No. 121917-57-5
(-)-MK 801 Maleate( (-)-MK 801 (Maleate) )
Catalog No. M17887 CAS No. 121917-57-5
MK-801 is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 46 | In Stock |
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| 10MG | 41 | In Stock |
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| 25MG | 70 | In Stock |
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| 50MG | 113 | In Stock |
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| 100MG | 212 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product Name(-)-MK 801 Maleate
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NoteResearch use only, not for human use.
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Brief DescriptionMK-801 is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.
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DescriptionMK-801 is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.
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In Vitro(-)-Dizocilpine maleate ((-)-MK-801 maleate) significantly inhibited the uptake of all three (norepinephrine, dopamine and serotonin) monoamine transporters in a dose-dependent manner in HEK cells. The Ki values of (-)-Dizocilpine on the norepinephrine, dopamine and serotonin transporters are 3.7 μM, 40 μM and 47 μM, respectively.
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In Vivo(-)-Dizocilpine maleate (0.1 mg/kg; intraperitoneal injection; male adult C57BL/6 mice) treatment induces rapid antidepressant effects in the social defeat stress model. Animal Model:Male adult C57BL/6 mice ( 20-25g; aged 8 weeks) with social defeat stress model Dosage:0.1 mg/kg Administration:Intraperitoneal injection Result:Induced rapid antidepressant effects in the social defeat stress model.
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Synonyms(-)-MK 801 (Maleate)
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PathwayOthers
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TargetOther Targets
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RecptorNMDA Receptor
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number121917-57-5
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Formula Weight337.37
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Molecular FormulaC20H19NO4
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 30 mg/mL; 88.92 mM
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SMILESO=C(O)/C=C\C(=O)O.C[C@]42N[C@@H](Cc1ccccc12)c3ccccc34
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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(-)-Epiafzelechin
(-)-Epiafzelechin exhibits significant anti-inflammatory activity on carrageenin-induced mouse paw edema, it exhibits a dose-dependent inhibition on the COX activity with an IC50 value of 15 microM, it exhibits about 3-fold weaker inhibitory potency on the enzyme activity than indomethacin as a positive control.
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Protein Kinase p34(c...
P34cdc2 Kinase Substrate Peptide is a synthetic peptide substrates for P34cdc2 kinase, with a Km of 74 μM for the purified human enzyme. P34cdc2 Kinase Substrate Peptide can be used in a rapid assay of P34cdc2 phosphorylation in vitro. P34cdc2, a protein serinehhreonine kinase, is a cell division cycle-regulated protein kinase.
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Pyrithione
Pyrithione is a transition metal complex, a zinc ionophore, that causes elevated zinc levels in mammalian cells. Pyrithione has potent bactericidal and antifungal activity.
