Hydrocoumarin

CAS No. 119-84-6

Hydrocoumarin( Hydrocoumarin | Chroman-2-one )

Catalog No. M17874 CAS No. 119-84-6

Spice, used in food, also used as a substitute for coumarin; used in cosmetics.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 28 In Stock
25MG 49 In Stock
100MG Get Quote In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Hydrocoumarin
  • Note
    Research use only, not for human use.
  • Brief Description
    Spice, used in food, also used as a substitute for coumarin; used in cosmetics.
  • Description
    Spice, used in food, also used as a substitute for coumarin; used in cosmetics.
  • In Vitro
    Dihydrocoumarin induces a concentration-dependent inhibition of SIRT1 (IC50 of 208 μM) in an in vitro enzymatic assay. A decrease in SIRT1 deacetylase activity is observed even at micromolar doses (85±5.8 and 73±13.7% activity at 1.6 μM and 8 μM, respectively). The microtubule SIRT2 deacetylase is also inhibited with a similar dose dependency (IC50 of 295 μM).Dihydrocoumarin (1-5 mM) increases cytotoxicity in the TK6 cell line in a dose-dependent manner following a 24-h exposure. Dihydrocoumarin (1-5 mM) increases apoptosis in a dose-dependent manner in the TK6 cell line at the 6-h time point. A 5-mM dose of Dihydrocoumarin increases apoptosis at the 6-h time point in the TK6 cell line.Dihydrocoumarin (1-5 mM) increases p53 lysine 373 and 382 acetylation in a dose-dependent manner in the TK6 cell line following a 24-h exposure period.
  • In Vivo
    ——
  • Synonyms
    Hydrocoumarin | Chroman-2-one
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    Others-Field
  • Indication
    ——

Chemical Information

  • CAS Number
    119-84-6
  • Formula Weight
    148.16
  • Molecular Formula
    C9H8O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (674.95 mM)
  • SMILES
    C1CC(=O)OC2=CC=CC=C21
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

molnova catalog
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