Hydrocoumarin

Research use only, not for human use.

Spice, used in food, also used as a substitute for coumarin; used in cosmetics.

Spice, used in food, also used as a substitute for coumarin; used in cosmetics.

Dihydrocoumarin induces a concentration-dependent inhibition of SIRT1 (IC50 of 208 μM) in an in vitro enzymatic assay. A decrease in SIRT1 deacetylase activity is observed even at micromolar doses (85±5.8 and 73±13.7% activity at 1.6 μM and 8 μM, respectively). The microtubule SIRT2 deacetylase is also inhibited with a similar dose dependency (IC50 of 295 μM).Dihydrocoumarin (1-5 mM) increases cytotoxicity in the TK6 cell line in a dose-dependent manner following a 24-h exposure. Dihydrocoumarin (1-5 mM) increases apoptosis in a dose-dependent manner in the TK6 cell line at the 6-h time point. A 5-mM dose of Dihydrocoumarin increases apoptosis at the 6-h time point in the TK6 cell line.Dihydrocoumarin (1-5 mM) increases p53 lysine 373 and 382 acetylation in a dose-dependent manner in the TK6 cell line following a 24-h exposure period.

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Hydrocoumarin | Chroman-2-one

Others

Other Targets

Others

Others-Field

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119-84-6

148.16

C9H8O2

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (674.95 mM)

C1CC(=O)OC2=CC=CC=C21

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(-20℃)

With Ice Pack

≥ 2 years