Icaritin

Research use only, not for human use.

Icaritin has hormone regulation activity and cardiovascular function improvement activity. Icaritin has anticancer activity, can induce S phase arrest and apoptosis, inhibit ENKL cell proliferation.

Icaritin is an oral traditional Chinese medicine, derived from barrenwort, which targets the estrogen receptor α36. IC50 values for Icaritin are 8,13 and 18 μM for K562, CML-CP and CML-BC cells respectively. Icaritin inhibits the invasion and epithelial-to-mesenchymal transition of glioblastoma cells by targeting EMMPRIN via PTEN/AKt/HIF-1α signalling. Icaritin suppresses hepatocellular carcinoma initiation and malignant growth through the IL-6/Jak2/Stat3 pathway. Icaritin activates JNK-dependent mPTP necrosis pathway in colorectal cancer cells.

Cell Proliferation Assay Cell Line:K562, imatinib-resistant cells and primary CML cells Concentration:4 μM, 8 μM, 16 μM, 32 μM and 64 μM Incubation Time:48 hours Result:Inhibited cell proliferation.Apoptosis Analysis Cell Line:K562 or primary cells Concentration:0 μM, 4 μM, 8 μM, 16 μM, 32 μM and 64 μM Incubation Time:48 hours Result:Induced K562 or primary cells apoptosis.Cell Cycle Analysis Cell Line:K562 cells Concentration: 32 μM Incubation Time:Result:Cell population in the sub-G1 phase was increased.Western Blot Analysis Cell Line:K562 cells Concentration:0 μM, 4 μM, 8 μM, 16 μM, 32 μM and 64 μM Incubation Time:48 hours Result:Inhibited MAPK/ERK/JNK downstream signaling and diminishes Jak2/Stat3/Akt expression.

Animal Model:Female NOD-SCID nude mice (6-8 weeks old) with K562 cells Dosage:4 mg/kg and 8 mg/kg Administration:Intraperitoneal injection; daily; for 10 weeks Result:Could prolong lifespan of NOD-SCID nude mice inoculated with K562 cells without suppression of bone marrow.

Icaritin

Others

Other Targets

JAK2| STAT3

Cancer

——

118525-40-9

368.38

C21H20O6

>98% (HPLC)

DMSO : 14 mg/mL 38.00 mM;

CC(=CCc1c(cc(c2c1oc(c(c2=O)O)c1ccc(cc1)OC)O)O)C

3,5,7-Trihydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one

(-20℃)

With Ice Pack

≥ 2 years