Epinastine HCl( Epinastine Hydrochloride | Alesion | Elestat )

Catalog No. M17804 CAS No. 108929-04-0

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Product Name

Epinastine HCl
Note

Research use only, not for human use.
Brief Description

Epinastine is an antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis.
Description

Epinastine Hydrochloride is a histamine H1 receptor antagonist without sedative activity. Epinastine hydrochloride blocks the histamine H1 receptor and inhibits the release of histamine from mast cells. This prevents the typical allergic symptoms that are caused by histamine activity on capillaries, skin, and mucous membranes. Typical histamine activities include vasodilation, bronchoconstriction, increased vascular permeability, pain, itching, and spasmodic contractions of gastrointestinal smooth muscles. Epinastine HCl also has affinity for histamine H2, 5-HT2, and the alpha-1, alpha-2 adrenergic receptors.
In Vitro

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In Vivo

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Synonyms

Epinastine Hydrochloride | Alesion | Elestat
Pathway

Others
Target

Other Targets
Recptor

HT
Research Area

Inflammation/Immunology
Indication

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CAS Number

108929-04-0
Formula Weight

285.77
Molecular Formula

C16H15N3·HCl
Purity

>98% (HPLC)
Solubility

In Vitro:?H2O : 100 mg/mL (349.93 mM)
SMILES

Cl[H].NC1=NCC2N1C1=CC=CC=C1CC1=CC=CC=C21
Chemical Name

3-Amino-9,13b-dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepine Hydrochloride

1. Fügner A, et al. Arzneimittelforschung, 1988, 38(10), 1446-1453.

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