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Esonarimod

CAS No. 101973-77-7

Esonarimod( Esonarimod | KE-298 | KE298 )

Catalog No. M17753 CAS No. 101973-77-7

Esonarimod is an antirheumatic drug.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 28 In Stock
25MG 46 In Stock
50MG 73 In Stock
100MG 116 In Stock
200MG 170 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Esonarimod
  • Note
    Research use only, not for human use.
  • Brief Description
    Esonarimod is an antirheumatic drug.
  • Description
    Esonarimod is an antirheumatic drug, suppressing lymphocyte activating factor activity or biosynthesis.(In Vitro):Esonarimod (KE-298) (10 to 300 μg/mL) suppresses the production of NO by RAW264.7 cells in a dose dependent manner. The IC50 of Esonarimod is 117.5 μg/mL. Esonarimod does not affect cellular viability at these tested doses. Esonarimod has no direct effect on NOS activity in cell-free extracts of RAW264.7 cells.(In Vivo):After repeated oral administration of Esonarimod (14C-KE-298), the radioactivity decreases rapidly and no tendency towards accumulation is found.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Esonarimod | KE-298 | KE298
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    IL-1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    101973-77-7
  • Formula Weight
    280.34
  • Molecular Formula
    C14H16O4S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC1=CC=C(C=C1)C(=O)CC(CSC(=O)C)C(=O)O
  • Chemical Name
    Benzenebutanoic acid, alpha-((acetylthio)methyl)-4-methyl-gamma-oxo-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Inoue T, et al. KE-298 and its active metabolite KE-758 suppress nitric oxide production by murine macrophage cells and peritoneal cells from rats with adjuvant induced arthritis. J Rheumatol. 2001 Jun;28(6):1229-37.
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