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Esonarimod
CAS No. 101973-77-7
Esonarimod( Esonarimod | KE-298 | KE298 )
Catalog No. M17753 CAS No. 101973-77-7
Esonarimod is an antirheumatic drug.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 28 | In Stock |
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| 25MG | 46 | In Stock |
|
| 50MG | 73 | In Stock |
|
| 100MG | 116 | In Stock |
|
| 200MG | 170 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameEsonarimod
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NoteResearch use only, not for human use.
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Brief DescriptionEsonarimod is an antirheumatic drug.
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DescriptionEsonarimod is an antirheumatic drug, suppressing lymphocyte activating factor activity or biosynthesis.(In Vitro):Esonarimod (KE-298) (10 to 300 μg/mL) suppresses the production of NO by RAW264.7 cells in a dose dependent manner. The IC50 of Esonarimod is 117.5 μg/mL. Esonarimod does not affect cellular viability at these tested doses. Esonarimod has no direct effect on NOS activity in cell-free extracts of RAW264.7 cells.(In Vivo):After repeated oral administration of Esonarimod (14C-KE-298), the radioactivity decreases rapidly and no tendency towards accumulation is found.
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In Vitro——
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In Vivo——
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SynonymsEsonarimod | KE-298 | KE298
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PathwayOthers
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TargetOther Targets
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RecptorIL-1
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Research Area——
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Indication——
Chemical Information
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CAS Number101973-77-7
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Formula Weight280.34
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Molecular FormulaC14H16O4S
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Purity>98% (HPLC)
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Solubility——
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SMILESCC1=CC=C(C=C1)C(=O)CC(CSC(=O)C)C(=O)O
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Chemical NameBenzenebutanoic acid, alpha-((acetylthio)methyl)-4-methyl-gamma-oxo-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Inoue T, et al. KE-298 and its active metabolite KE-758 suppress nitric oxide production by murine macrophage cells and peritoneal cells from rats with adjuvant induced arthritis. J Rheumatol. 2001 Jun;28(6):1229-37.
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