Ajmaline( Cardiorythmine | (+)-Ajmaline )

Catalog No. M17726 CAS No. 4360-12-7

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Product Name

Ajmaline
Note

Research use only, not for human use.
Brief Description

Ajmaline is a class Ia anti-arrhythmic compound that is widely used for the diagnosis of Brugada syndrome and the acute treatment of atrial or ventricular tachycardia.
Description

Ajmaline is a class Ia anti-arrhythmic compound that is widely used for the diagnosis of Brugada syndrome and the acute treatment of atrial or ventricular tachycardia. Ajmaline inhibits cardiac Kv1.5 and Kv4.3 channels at therapeutic concentrations.
In Vitro

Electrophysiological experiments are performed with human embryonic kidney (HEK) cells (whole-cell patch clamp) and Xenopus oocytes (double-electrode voltage clamp) expressing wild-type and mutant HERG channels. Ajmaline blocks HERG currents with an IC50 of 1.0μM in HEK cells and 42.3μM in Xenopus oocytes.
In Vivo

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Synonyms

Cardiorythmine | (+)-Ajmaline
Pathway

Autophagy
Target

CXCR
Recptor

sodium channel
Research Area

Cardiovascular Disease
Indication

——

CAS Number

4360-12-7
Formula Weight

326.4
Molecular Formula

C20H26N2O2
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 66 mg/mL; 202.19 mM
SMILES

CC[C@H]1[C@@H]2C[C@H]3[C@@H]4N(C)c5ccccc5[C@]44C[C@@H](C2[C@H]4O)N3[C@@H]1O
Chemical Name

——

1. Fischer F, et al. Naunyn-Schmiedeberg's Archives of Pharmacology, 2013, 386(11):991-999.

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