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PF 429242
CAS No. 947303-87-9
PF 429242( PF-429242 | PF 429242 | PF429242 )
Catalog No. M17686 CAS No. 947303-87-9
PF-429242 is a competitive inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease (IC50 = 0.175 μM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 95 | In Stock |
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| 2MG | 48 | In Stock |
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| 5MG | 95 | In Stock |
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| 10MG | 174 | In Stock |
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| 25MG | 385 | In Stock |
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| 50MG | 549 | In Stock |
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| 100MG | 799 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePF 429242
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NoteResearch use only, not for human use.
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Brief DescriptionPF-429242 is a competitive inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease (IC50 = 0.175 μM).
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DescriptionPF-429242 is a competitive inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease (IC50 = 0.175 μM). It is selective for site 1 protease against a panel of serine proteases. PF-429242 inhibits rate of cholesterol synthesis in CHO cells (IC50 = 0.53 μM).
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In Vitro——
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In Vivo——
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SynonymsPF-429242 | PF 429242 | PF429242
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PathwayCell Cycle/DNA Damage
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TargetGPR
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RecptorSREBP1
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Research Area——
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Indication——
Chemical Information
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CAS Number947303-87-9
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Formula Weight482.49
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Molecular FormulaC25H35N3O2·2HCl
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(c1ccc(CN(CC)CC)cc1)N(CCc1ccccc1OC)[C@@H]1CCNC1.Cl.Cl
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Chemical Name(R)-4-((diethylamino)methyl)-N-(2-methoxyphenethyl)-N-(pyrrolidin-3-yl)benzamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Monnerie H, Romer M, Jensen BK, Millar JS, Jordan-Sciutto KL, Kim SF, Grinspan JB. Reduced sterol regulatory element-binding protein (SREBP) processing through site-1 protease (S1P) inhibition alters oligodendrocyte differentiation in vitro. J Neurochem.
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