4-Oxofenretinide( 4-Oxo-4-HPR | 4-Oxo Fenretinide | 4-Keto-4-HPR )

Catalog No. M17628 CAS No. 865536-65-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

4-Oxofenretinide
Note

Research use only, not for human use.
Brief Description

4-oxo-fenretinide, a recently identified fenretinide metabolite, induces marked G2-M cell cycle arrest and apoptosis.
Description

4-Oxo-4-HPR is an inhibitor of tubulin polymerization, inducing marked G2-M cell cycle arrest and apoptosis in fenretinide-sensitive and fenretinide-resistant cell lines. It is also a fenretinide metabolite.
In Vitro

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In Vivo

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Synonyms

4-Oxo-4-HPR | 4-Oxo Fenretinide | 4-Keto-4-HPR
Pathway

GPCR/G Protein
Target

Prostaglandin Receptor
Recptor

cell cycle arrest and apoptosis
Research Area

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Indication

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CAS Number

865536-65-8
Formula Weight

405.53
Molecular Formula

C26H31NO3
Purity

>98% (HPLC)
Solubility

——
SMILES

CC1=C(C(CCC1=O)(C)C)/C=C/C(=C/C=C/C(=C/C(=O)Nc1ccc(cc1)O)/C)/C
Chemical Name

(2E,4E,6E,8E)-N-(4-Hydroxyphenyl)-3,7-dimethyl-9-(2,6,6-trimethyl-3-oxocyclohexen-1-yl)nona-2,4,6,8-tetraenamide

1.Villani MG,et al. Cancer Res. 2006 Mar 15;66(6):3238-47.

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