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BAW2881

CAS No. 861875-60-7

BAW2881( BAW2881 | BAW-2881 | BAW 2881 )

Catalog No. M17624 CAS No. 861875-60-7

BAW2881 is a potent and selective VEGFR inhibitor (vascular endothelial growth factor receptor tyrosine kinase inhibitor) with activity to inhibit chronic and acute skin inflammation.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 63 In Stock
2MG 41 In Stock
5MG 65 In Stock
10MG 111 In Stock
25MG 212 In Stock
50MG 335 In Stock
100MG 485 In Stock
200MG Get Quote In Stock
500MG 1088 In Stock
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Biological Information

  • Product Name
    BAW2881
  • Note
    Research use only, not for human use.
  • Brief Description
    BAW2881 is a potent and selective VEGFR inhibitor (vascular endothelial growth factor receptor tyrosine kinase inhibitor) with activity to inhibit chronic and acute skin inflammation.
  • Description
    BAW2881 is a potent and selective VEGFR inhibitor (vascular endothelial growth factor receptor tyrosine kinase inhibitor) with activity to inhibit chronic and acute skin inflammation. NVP-BAW2881 inhibited proliferation, migration, and tube formation by human umbilical vein endothelial cells and lymphatic endothelial cells in vitro. NVP-BAW2881 reduced the number of blood and lymphatic vessels and infiltrating leukocytes in the skin, and normalized the epidermal architecture. NVP-BAW2881 also displayed strong anti-inflammatory effects in models of acute inflammation; pretreatment with topical NVP-BAW2881 significantly inhibited VEGF-A-induced vascular permeability in the skin of pigs and mice.
  • In Vitro
    The VEGF-driven cellular receptor autophosphorylation in CHO cells of BAW2881 is inhibited with an IC50 of 4 nM. BAW2881 inhibits a limited number of kinases including c-RAF, B-RAF, RET, ABL, and TIE-2 at sub-μM IC50s. NVP-BAW2881 is highly selective for VEGFR, although it also demonstrates activity against Tie2 (IC50=650 nM) and RET (IC50=410 nM). The IC50 values of NVP-BAW2881 toward a wide panel of other kinases are >10 μM. NVP-BAW2881 inhibits VEGF-A-induced phosphorylation of VEGFR-2 in HUVECs and in VEGFR-2-transfected Chinese hamster ovary cells, with IC50 values of 2.9 and 4.2 nM, respectively.
  • In Vivo
    In a transgenic mouse model of psoriasis, NVP-BAW2881 reduces the number of blood and lymphatic vessels and infiltrating leukocytes in the skin, and normalized the epidermal architecture. NVP-BAW2881 also displays strong anti-inflammatory effects in models of acute inflammation; pretreatment with topical NVP-BAW2881 significantly inhibits VEGF-A-induced vascular permeability in the skin of pigs and mice.
  • Synonyms
    BAW2881 | BAW-2881 | BAW 2881
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    c-Abl| B-Raf (V599E)| C-Raf-1| hVEGFR2
  • Research Area
    Endocrinology
  • Indication
    ——

Chemical Information

  • CAS Number
    861875-60-7
  • Formula Weight
    424.38
  • Molecular Formula
    C22H15F3N4O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 33 mg/mL; 77.76 mM
  • SMILES
    O=C(c1c2ccc(Oc3nc(N)ncc3)cc2ccc1)Nc1cccc(C(F)(F)F)c1
  • Chemical Name
    6-((2-aminopyrimidin-4-yl)oxy)-N-(3-(trifluoromethyl)phenyl)-1-naphthamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Halin C, et al. Am J Pathol. 2008 Jul;173(1):265-77.
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