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TPI-1
CAS No. 79756-69-7
TPI-1( TPI-1 | TPI 1 | Tyrosine Phosphatase Inhibitor 1 )
Catalog No. M17598 CAS No. 79756-69-7
TPI-1 is a SHP-1 inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 117 | In Stock |
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| 2MG | 64 | In Stock |
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| 5MG | 105 | In Stock |
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| 10MG | 179 | In Stock |
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| 25MG | 350 | In Stock |
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| 50MG | 520 | In Stock |
|
| 100MG | 740 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTPI-1
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NoteResearch use only, not for human use.
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Brief DescriptionTPI-1 is a SHP-1 inhibitor.
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DescriptionTPI-1, also known as Tyrosine Phosphatase Inhibitor 1, is a SHP-1 inhibitor. TPI-1 selectively increased SHP-1 phospho-substrates (pLck-pY394, pZap70, and pSlp76) in Jurkat T cells but had little effects on pERK1/2 or pLck-pY505 regulated by phosphatases SHP-2 or CD45, respectively. TPI-1 induced mouse splenic-IFN-gamma(+) cells in vitro, approximately 58-fold more effective than sodium stibogluconate, and increased mouse splenic-pLck-pY394 and -IFN-gamma(+) cells in vivo.
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In VitroSHP-1 has been implicated as a potential cancer therapeutic target. TPI-1 is effective starting at 10 ng/mL in increasing SHP-1 phospho-substrates pLck-pY394. TPI-1 selectively increases SHP-1 phospho-substrates (pLck-pY394, pZap70 and pSlp76) in Jurkat T cells but has little effects on pERK1/2 or pLck-pY505. TPI-1 induces mouse splenic-IFNγ+ cells and induces IFNγ+ cells in human peripheral blood.
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In VivoTPI-1 inhibits the growth of B16 melanoma tumors in mice at a tolerated oral dose in a T cell-dependent manner but has little effects on B16 cell growth in culture. TPI-1 thus also increases pLck-pY394 and IFNγ+ cells in mice. TPI-1 also inhibits B16 tumor growth and prolongs tumor mice survival as a tolerated s.c. agent.
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SynonymsTPI-1 | TPI 1 | Tyrosine Phosphatase Inhibitor 1
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PathwayOthers
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TargetOther Targets
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Recptorrecombinant SHP-1
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number79756-69-7
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Formula Weight253.08
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Molecular FormulaC12H6Cl2O2
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Purity>98% (HPLC)
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SolubilityDMSO : 50 mg/mL 197.57 mM;
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SMILESc1cc(c(cc1Cl)C1=CC(=O)C=CC1=O)Cl
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Chemical Name2-(2,5-dichlorophenyl)-2,5-cyclohexadiene-1,4-dione
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kundu S, et al. Novel SHP-1 inhibitors tyrosine phosphatase inhibitor-1 and analogs with preclinical anti-tumor activities as tolerated oral agents. J Immunol. 2010 Jun 1;184(11):6529-36.
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