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Vorapaxar sulfate

CAS No. 705260-08-8

Vorapaxar sulfate( —— )

Catalog No. M17571 CAS No. 705260-08-8

Vorapaxar sulfate is a potent and orally active thrombin receptor (PAR-1) antagonist.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Vorapaxar sulfate
  • Note
    Research use only, not for human use.
  • Brief Description
    Vorapaxar sulfate is a potent and orally active thrombin receptor (PAR-1) antagonist.
  • Description
    Vorapaxar sulfate is a potent and orally active thrombin receptor (PAR-1) antagonist.(In Vitro):Vorapaxar sulfate (SCH 530348 sulfate) shows potent inhibition of thrombin-induced platelet aggregation with an IC50 of 47 nM and haTRAP-induced platelet aggregation with an IC50 of 25 nM. Vorapaxar sulfate (SCH 530348 sulfate) inhibits thrombininduced calcium transient in human coronary artery smooth muscle cells (HCASMC) with a Ki of 1.1 nM. It also inhibits thrombin-stimulated thymidine incorporation in HCASMC with a Ki of 13 nM.
  • In Vitro
    Vorapaxar sulfate (SCH 530348 sulfate) shows potent inhibition of thrombin-induced platelet aggregation with an IC50 of 47 nM and haTRAP-induced platelet aggregation with an IC50 of 25 nM. Vorapaxar sulfate (SCH 530348 sulfate) inhibits thrombininduced calcium transient in human coronary artery smooth muscle cells (HCASMC) with a Ki of 1.1 nM. It also inhibits thrombin-stimulated thymidine incorporation in HCASMC with a Ki of 13 nM.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    PAR-1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    705260-08-8
  • Formula Weight
    590.66
  • Molecular Formula
    C29H35FN2O8S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (211.63 mM)
  • SMILES
    S(=O)(=O)(O)O.Fc1cc(c2cnc(/C=C/[C@@H]3[C@H]4[C@@H](C[C@H]5[C@H]3CC[C@@H](NC(=O)OCC)C5)C(=O)O[C@@H]4C)cc2)ccc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Chackalamannil S, et al. J Med Chem, 2008, 51(11), 3061-3064.
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