GW 441756( GW-441756 | GW 441756 | GW441756 )

Catalog No. M17527 CAS No. 504433-23-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

GW 441756
Note

Research use only, not for human use.
Brief Description

GW 441756 is a specific Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 value of 2 nM.
Description

GW-441756 is a potent inhibitor of TrkA (IC50 = 2 nM). Trk inhibition reduces cell proliferation and potentiates the effects of chemotherapeutic agents in Ewing sarcoma.
In Vitro

Immunofluorescence Cell Line:Spinal cord neurons cells Concentration:1 μM Incubation Time:48 hours Result:Abolished BmK NSPK-induced neurite outgrowth.
In Vivo

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Synonyms

GW-441756 | GW 441756 | GW441756
Pathway

Endocrinology/Hormones
Target

AChR
Recptor

CDK2| C-Raf-1| TrkA
Research Area

Cancer
Indication

——

CAS Number

504433-23-2
Formula Weight

275.3
Molecular Formula

C17H13N3O
Purity

>98% (HPLC)
Solubility

DMSO : 17.5 mg/mL. 63.57 mM; H2O : < 0.1 mg/mL
SMILES

Cn1cc(c2ccccc12)C=C1c2c(cccn2)NC1=O
Chemical Name

1,3-dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2H-pyrrolo[3,2-b]pyridin-2-one

1. Wood ER, et al. Bioorg Med Chem Lett, 2004, 14(4), 953-957.

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