L67

Research use only, not for human use.

L67 is a competitive human DNA ligase inhibitor, inhibits DNA ligases I and III (IC50: 10 μM).

L67 is a DNA Ligase Inhibitor. L67 inhibited DNA ligases I and III. L67 is a simple competitive inhibitor with respect to nicked DNA. L67 inhibits DNA ligases I and III with IC values of 10 μM and 10 μM.). L67 significantly increased the cytotoxicity of DNA-damaging.

Cell Viability Assay Cell Line:HeLa cells Concentration:10, 15 μM; 0-50 μM Incubation Time:24 h Result:Increased the formation of nuclear γH2AX foci and steady state levels of γH2AX when at 10 or 15 μM. (γH2AX: a sign of DNA double-strand breaks).Resulted in a concentration (0-50 μM)-dependent increase in mSOX (mitochondrial superoxide) levels. (mSOX is a major cause of the cellular oxidative damage).Cell Viability Assay Cell Line:HeLa cells Concentration:10 μM Incubation Time:24 h Result:Reduced oxygen consumption rate (OCR) approximately 20%.Resulted in about a 25% reduction in mitochondrial DNA.Apoptosis Analysis Cell Line:HeLa cells Concentration:10, 100 μM Incubation Time:24 h Result:Result:Induced apoptosis, and at 100 μM with apoptotic cells constituting about 50% of the HeLa cell population.Cell Viability Assay Cell Line:HeLa cells Concentration:0-30 μM Incubation Time:24 h Result:Activates a caspase 1-dependent cell death pathway in cancer cells.

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L67 | L-67 | L 67

Tyrosine Kinase

Trk Receptor

DNA ligases

Cancer

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325970-71-6

486.11

C16H14Br2N4O4

>98% (HPLC)

DMSO : ≥ 33 mg/mL; 67.89 mM

Cc1c(Br)cc(NCC(=O)N\N=C\c2cc(ccc2O)[N+]([O-])=O)cc1Br

E-2-((3,5-Dibromo-4-methylphenyl)amino)-N’-(2-hydroxy-5-nitrobenzylidene)acetohydrazide

(-20℃)

With Ice Pack

≥ 2 years