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Pardoprunox hydrochloride
CAS No. 269718-83-4
Pardoprunox hydrochloride( SLV-308 hydrochloride | DU-126891 hydrochloride )
Catalog No. M17462 CAS No. 269718-83-4
Pardoprunox hydrochloride is a novel partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 29 | In Stock |
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| 5MG | 42 | In Stock |
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| 10MG | 69 | In Stock |
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| 25MG | 117 | In Stock |
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| 50MG | 184 | In Stock |
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| 100MG | 346 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NamePardoprunox hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionPardoprunox hydrochloride is a novel partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist.
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DescriptionPardoprunox hydrochloride is a novel partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist, D2 (pKi = 8.1) and D3 receptor (pKi = 8.6) partial agonist and 5-HT1A receptor (pKi = 8.5) full agonist.(In Vitro):Pardoprunox (SLV-308) hydrochloride acts as a potent but partial D2 receptor agonist (pEC50= 8.0 and pA2=8.4) with an efficacy of 50% on forskolin stimulated cAMP accumulation. At human recombinant dopamine D3 receptors, Pardoprunox hydrochloride acts as a partial agonist in the induction of [(35)S]GTPgammaS binding (intrinsic activity of 67%; pEC50=9.2) and antagonized the dopamine induction of [(35)S]GTPgammaS binding (pA2=9.0). Pardoprunox hydrochloride acts as a full 5-HT1A receptor agonist on forskolin induced cAMP accumulation at cloned human 5-HT1A receptors but with low potency (pEC50=6.3).
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In VitroPardoprunox (SLV-308) hydrochloride acts as a potent but partial D2 receptor agonist (pEC50= 8.0 and pA2=8.4) with an efficacy of 50% on forskolin stimulated cAMP accumulation. At human recombinant dopamine D3 receptors, Pardoprunox hydrochloride acts as a partial agonist in the induction of [(35)S]GTPgammaS binding (intrinsic activity of 67%; pEC50=9.2) and antagonized the dopamine induction of [(35)S]GTPgammaS binding (pA2=9.0). Pardoprunox hydrochloride acts as a full 5-HT1A receptor agonist on forskolin induced cAMP accumulation at cloned human 5-HT1A receptors but with low potency (pEC50=6.3).
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In Vivo——
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SynonymsSLV-308 hydrochloride | DU-126891 hydrochloride
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PathwayMAPK/ERK Signaling
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Targetp38 MAPK
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Recptor5-HT1A| D2| D3
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number269718-83-4
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Formula Weight269.73
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Molecular FormulaC12H16ClN3O2
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Purity>98% (HPLC)
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SolubilityH2O : < 0.1 mg/mL
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SMILESO=c1oc2c(N3CCN(C)CC3)cccc2[nH]1.Cl.Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Glennon JC, et al.Synapse. 2006 Dec 15;60(8):599-608.
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