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EBE-A22

CAS No. 229476-53-3

EBE-A22( EBE-A22 | EBE A22 | EBEA22 )

Catalog No. M17448 CAS No. 229476-53-3

EBE-A22 is a derivative of PD 153035 which can inhibit ErbB-1-phosphorylation, whereas EBE-A22 is inactive.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    EBE-A22
  • Note
    Research use only, not for human use.
  • Brief Description
    EBE-A22 is a derivative of PD 153035 which can inhibit ErbB-1-phosphorylation, whereas EBE-A22 is inactive.
  • Description
    EBE-A22 is a derivative of PD 153035. EBE-A22, has no effect on EGF-R TK but maintains a high cytotoxic profile. EBE-A22 binds to DNA and behave as typical intercalating agents. EBE-A22 unwinds supercoiled plasmid, stabilizes duplex DNA against heat denaturation, and produces negative CD and ELD signals, as expected for an intercalating agent. EBE-A22, but not PD153035, interacts preferentially with GC-rich sequences and discriminates against homooligomeric runs of A and T which are often cut more readily by the enzyme in the presence of the drug compared to the control.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    EBE-A22 | EBE A22 | EBEA22
  • Pathway
    Angiogenesis
  • Target
    FGFR
  • Recptor
    EGFR/ErbB1
  • Research Area
    Others-Field
  • Indication
    ——

Chemical Information

  • CAS Number
    229476-53-3
  • Formula Weight
    374.23
  • Molecular Formula
    C17H16BrN3O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 50 mg/mL 133.61 mM; H2O : < 0.1 mg/mL
  • SMILES
    CN(c1cc(ccc1)Br)c1ncnc2cc(c(cc12)OC)OC
  • Chemical Name
    N-(3-bromophenyl)-6,7-dimethoxy-N-methylquinazolin-4-amine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Goossens JF, et al. DNA interaction of the tyrosine protein kinase inhibitor PD153035 and its N-methyl analogue. Biochemistry. 2001 Apr 17;40(15):4663-71.
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