AM281( AM281 | AM 281 | AM-281 )

Catalog No. M17418 CAS No. 202463-68-1

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Product Name

AM281
Note

Research use only, not for human use.
Brief Description

AM 281, a cannabinoid antagonist, reduces neurologic dysfunction and mortality rate after cecal ligation and puncture in rats.
Description

AM281 is a synthetic cannabinoid CB1 receptor antagonist.
In Vitro

——
In Vivo

Animal Model:Male NMRI mice with the weight of 25-30 gDosage:0.62, 1.25 and 2.5 mg/kg (chronic administration); 2.5, 5 and 10 mg/kg (acute administration) Administration:Administrated i.p. every day concurrently with morphine except the day of experiment (chronic administration); Singly injected 40 min before second trial (acute administration)Result:The simultaneous daily administration of AM281 with morphine significantly shortened the exploration time, as compared with morphine-dependent mice receiving vehicle. Acute administration at a dose of 5 mg/kg, significantly augmented recognition index.
Synonyms

AM281 | AM 281 | AM-281
Pathway

Microbiology/Virology
Target

HCV
Recptor

CB
Research Area

——
Indication

——

CAS Number

202463-68-1
Formula Weight

557.21
Molecular Formula

C21H19Cl2IN4O2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 7.14 mg/mL (12.81 mM)
SMILES

Ic1ccc(c2n(nc(c2C)C(=O)NN2CCOCC2)c2c(Cl)cc(Cl)cc2)cc1
Chemical Name

1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-morpholin-4-ylpyrazole-3-carboxamide

1. Kadoi Y, et al. Crit Care Med. 2005 Nov;33(11):2629-36.

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