Lomitapide( AEGR-733 | BMS-201038 )

Catalog No. M17390 CAS No. 182431-12-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

Lomitapide
Note

Research use only, not for human use.
Brief Description

Lomitapide is a small molecule inhibitor of microsomal triglyceride transfer protein (MTP), an enzyme located in the lumen of the endoplasmic reticulum responsible for absorbing dietary lipids and transferring triglycerides onto apolipoprotein B (apo-B) in the assembly of very-low-density lipoprotein.
Description

Lomitapide is a small molecule inhibitor of microsomal triglyceride transfer protein (MTP), an enzyme located in the lumen of the endoplasmic reticulum responsible for absorbing dietary lipids and transferring triglycerides onto apolipoprotein B (apo-B) in the assembly of very-low-density lipoprotein.
In Vitro

——
In Vivo

——
Synonyms

AEGR-733 | BMS-201038
Pathway

PI3K/Akt/mTOR signaling
Target

S6 Kinase
Recptor

MTP
Research Area

Cardiovascular Disease
Indication

——

CAS Number

182431-12-5
Formula Weight

692.71
Molecular Formula

C39H37F6N3O2
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 35 mg/mL; 50.45 mM
SMILES

c1cccc2c1C(c1c2cccc1)(CCCCN1CCC(CC1)NC(=O)c1c(cccc1)c1ccc(cc1)C(F)(F)F)C(=O)NCC(F)(F)F
Chemical Name

——