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Lomitapide
CAS No. 182431-12-5
Lomitapide( AEGR-733 | BMS-201038 )
Catalog No. M17390 CAS No. 182431-12-5
Lomitapide is a small molecule inhibitor of microsomal triglyceride transfer protein (MTP), an enzyme located in the lumen of the endoplasmic reticulum responsible for absorbing dietary lipids and transferring triglycerides onto apolipoprotein B (apo-B) in the assembly of very-low-density lipoprotein.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 156 | In Stock |
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| 2MG | 56 | In Stock |
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| 5MG | 91 | In Stock |
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| 10MG | 141 | In Stock |
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| 25MG | 231 | In Stock |
|
| 50MG | 325 | In Stock |
|
| 100MG | 488 | In Stock |
|
| 200MG | 701 | In Stock |
|
| 500MG | 1079 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameLomitapide
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NoteResearch use only, not for human use.
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Brief DescriptionLomitapide is a small molecule inhibitor of microsomal triglyceride transfer protein (MTP), an enzyme located in the lumen of the endoplasmic reticulum responsible for absorbing dietary lipids and transferring triglycerides onto apolipoprotein B (apo-B) in the assembly of very-low-density lipoprotein.
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DescriptionLomitapide is a small molecule inhibitor of microsomal triglyceride transfer protein (MTP), an enzyme located in the lumen of the endoplasmic reticulum responsible for absorbing dietary lipids and transferring triglycerides onto apolipoprotein B (apo-B) in the assembly of very-low-density lipoprotein.
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In Vitro——
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In Vivo——
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SynonymsAEGR-733 | BMS-201038
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PathwayPI3K/Akt/mTOR signaling
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TargetS6 Kinase
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RecptorMTP
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Research AreaCardiovascular Disease
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Indication——
Chemical Information
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CAS Number182431-12-5
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Formula Weight692.71
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Molecular FormulaC39H37F6N3O2
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 35 mg/mL; 50.45 mM
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SMILESc1cccc2c1C(c1c2cccc1)(CCCCN1CCC(CC1)NC(=O)c1c(cccc1)c1ccc(cc1)C(F)(F)F)C(=O)NCC(F)(F)F
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Davis KA, Miyares MA. Am J Health Syst Pharm. 2014 Jun 15;71(12):1001-8.
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