AN2718

Research use only, not for human use.

AN2718 is a benzoxaborole compound that displays broad antifungal effectiveness in vitro.

AN2718 is a novel boron-containing small molecule that inhibits an essential protein synthesis enzyme, leucyl-transfer RNA synthetase, or LeuRS. This enzyme plays an essential role in fungal protein synthesis by attaching the leucine amino acid to transfer RNA, or tRNA. AN2718, an investigational topical anti-fungal product candidate for the potential treatment of skin and nail infections. At various concentrations, AN2718 gel showed low irritation potential, leading investigators to conclude that application site reactions in future efficacy trials would be unlikely.(In Vitro):AN2718 inhibits cytoplasmic LeuRS from molds, A. fumigatus, and from yeasts, C. albicans, with an IC50 of 2 μM and 4.2 μM, respectively. AN2718 has good MIC90 activity against the dermatophytes, T. rubrum and T.mentagrophytes.

AN2718 inhibits cytoplasmic LeuRS from molds, A. fumigatus, and from yeasts, C. albicans, with an IC50 of 2 μM and 4.2 μM, respectively. AN2718 has good MIC90 activity against the dermatophytes, T. rubrum and T.mentagrophytes.

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AN2718 | AN-2718 | AN 2718

Metabolic Enzyme/Protease

DPP

leucyl-tRN/A synthetase

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174672-06-1

168.4

C7H6BClO2

>98% (HPLC)

In Vitro:?DMSO : ≥ 50 mg/mL (296.93 mM)

c12c(ccc(c1)Cl)B(OC2)O

5-chlorobenzo[c][1,2]oxaborol-1(3H)-ol

(-20℃)

With Ice Pack

≥ 2 years