ML355
CAS No. 1532593-30-8
ML355( ML355 | ML 355 | ML-355 )
Catalog No. M17333 CAS No. 1532593-30-8
ML355, a specific, effective 12-Lipoxygenase(12-LOX) inhibitors(IC50=0.34 μM), possess favorable ADME properties.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 98 | In Stock |
|
| 5MG | 93 | In Stock |
|
| 10MG | 155 | In Stock |
|
| 25MG | 297 | In Stock |
|
| 50MG | 477 | In Stock |
|
| 100MG | 732 | In Stock |
|
| 200MG | 995 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameML355
-
NoteResearch use only, not for human use.
-
Brief DescriptionML355, a specific, effective 12-Lipoxygenase(12-LOX) inhibitors(IC50=0.34 μM), possess favorable ADME properties.
-
DescriptionML355 is a potent and selective inhibitor of human 12-lipoxygenase.
-
In VitroML355 inhibits PAR-4 induced aggregation and calcium mobilization in human platelets and reduce 12-HETE in β-cells.
-
In VivoML355 (1.88-30 mg/kg; i.g.; 2 times per day for two days) strongly inhibits the thrombus formation in mice at higher dose compared to WT controls. Animal Model:C57BL/6 mice Dosage:1.88, 3.75, 7.5, 15, 30 mg/kg Administration:Oral gavage; 2 times per day for two days Result:The thrombus formation in mice was strongly inhibited by higher doses of ML355.
-
SynonymsML355 | ML 355 | ML-355
-
PathwayOthers
-
TargetOther Targets
-
Recptor12-Lipoxygenase
-
Research AreaInflammation/Immunology|Neurological Disease
-
Indication——
Chemical Information
-
CAS Number1532593-30-8
-
Formula Weight441.52
-
Molecular FormulaC21H19N3O4S2
-
Purity>98% (HPLC)
-
SolubilityDMSO : ≥ 42 mg/mL. 95.13 mM
-
SMILESCOC1=CC=CC(=C1O)CNC2=CC=C(C=C2)S(=O)(=O)NC3=NC4=CC=CC=C4S3
-
Chemical NameN-2-benzothiazolyl-4-[[(2-hydroxy-3-methoxyphenyl)methyl]amino]-benzenesulfonamide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Luci DK, et al. J Med Chem. 2014 Jan 23;57(2):495-506.
molnova catalog
related products
-
Ethacridine lactate ...
Ethacridine lactate monohydrate is an aromatic organic compound based on acridine used as an antiseptic agent.
-
FEN1-IN-1
FEN1-IN-1 is an inhibitor of flap endonuclease 1 (FEN1). FEN1-IN-1 binds to the active site of FEN1. It partly achieves inhibition by the co-ordination of Mg2+ ions.
-
(1S,2S)-threo-Honoki...
(1S,2S)-threo-Honokitriol is a natural product of Magnolia, Magnoliaceae. (1S,2S)-threo-Honokitriol can be used as a reference standard.
Cart
sales@molnova.com