ML355( ML355 | ML 355 | ML-355 )

Catalog No. M17333 CAS No. 1532593-30-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

ML355
Note

Research use only, not for human use.
Brief Description

ML355, a specific, effective 12-Lipoxygenase(12-LOX) inhibitors(IC50=0.34 μM), possess favorable ADME properties.
Description

ML355 is a potent and selective inhibitor of human 12-lipoxygenase.
In Vitro

ML355 inhibits PAR-4 induced aggregation and calcium mobilization in human platelets and reduce 12-HETE in β-cells.
In Vivo

ML355 (1.88-30 mg/kg; i.g.; 2 times per day for two days) strongly inhibits the thrombus formation in mice at higher dose compared to WT controls. Animal Model:C57BL/6 mice Dosage:1.88, 3.75, 7.5, 15, 30 mg/kg Administration:Oral gavage; 2 times per day for two days Result:The thrombus formation in mice was strongly inhibited by higher doses of ML355.
Synonyms

ML355 | ML 355 | ML-355
Pathway

Others
Target

Other Targets
Recptor

12-Lipoxygenase
Research Area

Inflammation/Immunology|Neurological Disease
Indication

——

CAS Number

1532593-30-8
Formula Weight

441.52
Molecular Formula

C21H19N3O4S2
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 42 mg/mL. 95.13 mM
SMILES

COC1=CC=CC(=C1O)CNC2=CC=C(C=C2)S(=O)(=O)NC3=NC4=CC=CC=C4S3
Chemical Name

N-2-benzothiazolyl-4-[[(2-hydroxy-3-methoxyphenyl)methyl]amino]-benzenesulfonamide

1.Luci DK, et al. J Med Chem. 2014 Jan 23;57(2):495-506.

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