XEN-445( XEN445 | XEN 445 | XEN-445 )

Catalog No. M17330 CAS No. 1515856-92-4

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

XEN-445
Note

Research use only, not for human use.
Brief Description

XEN445, a potent and selective endothelial lipase(EL) inhibitor (IC50=0.237 uM), exhibitis good ADME and PK properties.
Description

XEN445 is potent and selective endothelial lipase inhibitor, that showed good ADME and PK properties, and demonstrated in vivo efficacy in raising plasma HDLc concentrations in mice. Endothelial lipase (EL) activity has been implicated in HDL metabolism and in atherosclerotic plaque development; inhibitors are proposed to be efficacious in the treatment of dyslipidemia related cardiovascular disease.
In Vitro

——
In Vivo

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Synonyms

XEN445 | XEN 445 | XEN-445
Pathway

Endocrinology/Hormones
Target

5-HT Receptor
Recptor

endothelial lipase
Research Area

Cardiovascular Disease
Indication

——

CAS Number

1515856-92-4
Formula Weight

366.33
Molecular Formula

C18H17F3N2O3
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 40 mg/mL. 109.19 mM
SMILES

c1(ccc(c(c1)C(=O)O)N1C[C@H](CC1)OCc1ncccc1)C(F)(F)F
Chemical Name

(S)-2-(3-(pyridin-2-ylmethoxy)pyrrolidin-1-yl)-5-(trifluoromethyl)benzoic acid

1. Sun S, et al. Bioorg Med Chem. 2013, 21(24), 7724-7734.

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