Cart
sales@molnova.com
XEN-445
CAS No. 1515856-92-4
XEN-445( XEN445 | XEN 445 | XEN-445 )
Catalog No. M17330 CAS No. 1515856-92-4
XEN445, a potent and selective endothelial lipase(EL) inhibitor (IC50=0.237 uM), exhibitis good ADME and PK properties.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 35 | In Stock |
|
| 5MG | 31 | In Stock |
|
| 10MG | 60 | In Stock |
|
| 25MG | 113 | In Stock |
|
| 50MG | 206 | In Stock |
|
| 100MG | 319 | In Stock |
|
| 200MG | 453 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameXEN-445
-
NoteResearch use only, not for human use.
-
Brief DescriptionXEN445, a potent and selective endothelial lipase(EL) inhibitor (IC50=0.237 uM), exhibitis good ADME and PK properties.
-
DescriptionXEN445 is potent and selective endothelial lipase inhibitor, that showed good ADME and PK properties, and demonstrated in vivo efficacy in raising plasma HDLc concentrations in mice. Endothelial lipase (EL) activity has been implicated in HDL metabolism and in atherosclerotic plaque development; inhibitors are proposed to be efficacious in the treatment of dyslipidemia related cardiovascular disease.
-
In Vitro——
-
In Vivo——
-
SynonymsXEN445 | XEN 445 | XEN-445
-
PathwayEndocrinology/Hormones
-
Target5-HT Receptor
-
Recptorendothelial lipase
-
Research AreaCardiovascular Disease
-
Indication——
Chemical Information
-
CAS Number1515856-92-4
-
Formula Weight366.33
-
Molecular FormulaC18H17F3N2O3
-
Purity>98% (HPLC)
-
SolubilityDMSO : ≥ 40 mg/mL. 109.19 mM
-
SMILESc1(ccc(c(c1)C(=O)O)N1C[C@H](CC1)OCc1ncccc1)C(F)(F)F
-
Chemical Name(S)-2-(3-(pyridin-2-ylmethoxy)pyrrolidin-1-yl)-5-(trifluoromethyl)benzoic acid
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Sun S, et al. Bioorg Med Chem. 2013, 21(24), 7724-7734.
molnova catalog
related products
-
Allopurinol Sodium
Allopurinol Sodium is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM.
-
Homoeriodictyol
Homoeriodictyol, a naturally occurring, bitter-masking flavanone, as a promising agent to increase appetite and food intake. The flavanone homoeriodictyol can increase SGLT-1-mediated glucose uptake but decrease serotonin release in differentiated Caco-2 cells.In contrast to other polyphenols, the flavanon Homoeriodictyol promotes glucose uptake by 29.0 ± 3.83% at a concentration of 100 μM.
-
YL0919
An orally active, dual 5-HT1A agonist and selective serotonin reuptake inhibitor with Ki of 0.19 nM and IC50 of 1.78 nM, respectively.
