Hederacoside C( Kalopanaxsaponin B | Hederacoside C | Hederoside H1 )

Catalog No. M17289 CAS No. 14216-03-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

Hederacoside C
Note

Research use only, not for human use.
Brief Description

Hederacoside C is expectorant for Cold and cough relief, Bronchitis.
Description

Mutant EGFR inhibitor is a selective and potent Mutated EGFR inhibitor, inhibits L858R activating mutant, the Exonl9 deletion activating mutant and the T790M resistance mutant.
In Vitro

Western Blot Analysis Cell Line: Caco-2 Concentration:0.1, 1, 10 μM Incubation Time:1 h Result:Reduced the expression of p-p65/p65, p-JNK, p-ERK, and p-p38.RT-PCR Cell Line:RAW 264.7 Concentration:5, 10, 50 μg/mL Incubation Time:1 h Result:Reduced the expressions of IL-1β, IL-6, TNF-α, and IL-10.
In Vivo

Animal Model:TNBS-induced colitis in rat Dosage:0.625, 1.25, 2.5 mg/kg Administration:i.p.Result:Decreased the levels of inflammatory cytokines, including TNF-α, IL-6, IL-1β, CXCL-1, CXCL-2, and CXCL-5.Reduced cell apoptosis in TNBS-induced colitis.Reduced Bax/Bcl-2 ratio, cleaved caspase 3, and p53 protein levels in a dose-dependent manner.
Synonyms

Kalopanaxsaponin B | Hederacoside C | Hederoside H1
Pathway

GPCR/G Protein
Target

Histamine Receptor
Recptor

Others
Research Area

Infection
Indication

——

CAS Number

14216-03-6
Formula Weight

1221.39
Molecular Formula

C59H96O26
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (81.87 mM)
SMILES

[C@@H]1([C@@H](OC[C@@H]([C@@H]1O)O)O[C@@H]1[C@]([C@H]2[C@@]([C@@H]3[C@]([C@]4(C(=CC3)[C@H]3[C@@](CC4)(CCC(C3)(C)C)C(=O)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO[C@H]3[C@@H]([C@H]([C@H](O[C@H]4[C@@H]([C@@H]([C@H]([C@@H](O4)C)O)O)O)[C@H](O3)CO)O)O)O)O)O)C)(CC2)C)(CC1)C)(CO)C)O[C@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)C)O)O)O
Chemical Name

Olean-12-en-28-oic acid, 3- ((2-O-(6-deoxy-alpha-L-mannopyranosyl)-alpha-L-arabinopyranosyl)oxy)-23-hydroxy-, O-6-deoxy-alpha-L-mannopyranosyl-(1-4)-O-beta-D-glucopyranosyl-(1-6)-beta-D-glucopyranosyl ester, (3beta,4alpha)-

1. Kim JM, et al. Xenobiotica. 2013 Nov;43(11):985-92.;

Calculator

molnova catalog