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ML239
CAS No. 1378872-36-6
ML239( —— )
Catalog No. M17266 CAS No. 1378872-36-6
ML239 is a potent and selective inhibitor of breast cancer stem cells, with an IC50 of 1.16 μM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 28 | In Stock |
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| 10MG | 29 | In Stock |
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| 25MG | 57 | In Stock |
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| 50MG | 109 | In Stock |
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| 100MG | 186 | In Stock |
|
| 200MG | 272 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameML239
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NoteResearch use only, not for human use.
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Brief DescriptionML239 is a potent and selective inhibitor of breast cancer stem cells, with an IC50 of 1.16 μM.
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DescriptionML239 is a potent and selective inhibitor of breast cancer stem cells, with an IC50 of 1.16 μM.
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In VitroML239 (Compound 7j) is a potent and selective inhibitor of breast cancer stem cells, with an IC50 of 1.16 μM, with ～24-fold selectivity against the control cell line. ML239 inhibits breast cancer stem-like cells, most likely through activation of fatty acid desaturase 2 (FADS2). ML239 is cytotoxic to NCIH661 cells, and FADS2 knockdown reduces ML239 cytotoxicity, and furthermore, FADS2 inhibitor SC-26196 also reduces ML239 cytotoxicity in cancer cell lines (CCLs).
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In Vivo——
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Synonyms——
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PathwayPI3K/Akt/mTOR signaling
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TargetmTOR
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RecptorOthers
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1378872-36-6
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Formula Weight346.59
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Molecular FormulaC13H10Cl3N3O2
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 300 mg/mL 865.55 mM
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SMILESClc2cc(Cl)cc(Cl)c2OCC(=O)N\N=C\c1cccn1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Germain AR,etal.Identification of a selective small molecule inhibitor of breast cancer stem cells.Bioorg Med Chem Lett. 2012 May 15;22(10):3571-4.
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