Cart
sales@molnova.com
ML239
CAS No. 1378872-36-6
ML239( —— )
Catalog No. M17266 CAS No. 1378872-36-6
ML239 is a potent and selective inhibitor of breast cancer stem cells, with an IC50 of 1.16 μM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 39 | In Stock |
|
| 10MG | 65 | In Stock |
|
| 25MG | 129 | In Stock |
|
| 50MG | 250 | In Stock |
|
| 100MG | 429 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameML239
-
NoteResearch use only, not for human use.
-
Brief DescriptionML239 is a potent and selective inhibitor of breast cancer stem cells, with an IC50 of 1.16 μM.
-
DescriptionML239 is a potent and selective inhibitor of breast cancer stem cells, with an IC50 of 1.16 μM.
-
In VitroML239 (Compound 7j) is a potent and selective inhibitor of breast cancer stem cells, with an IC50 of 1.16 μM, with ～24-fold selectivity against the control cell line. ML239 inhibits breast cancer stem-like cells, most likely through activation of fatty acid desaturase 2 (FADS2). ML239 is cytotoxic to NCIH661 cells, and FADS2 knockdown reduces ML239 cytotoxicity, and furthermore, FADS2 inhibitor SC-26196 also reduces ML239 cytotoxicity in cancer cell lines (CCLs).
-
In Vivo——
-
Synonyms——
-
PathwayPI3K/Akt/mTOR signaling
-
TargetmTOR
-
RecptorOthers
-
Research AreaCancer
-
Indication——
Chemical Information
-
CAS Number1378872-36-6
-
Formula Weight346.59
-
Molecular FormulaC13H10Cl3N3O2
-
Purity>98% (HPLC)
-
SolubilityDMSO : ≥ 300 mg/mL 865.55 mM
-
SMILESClc2cc(Cl)cc(Cl)c2OCC(=O)N\N=C\c1cccn1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Germain AR,etal.Identification of a selective small molecule inhibitor of breast cancer stem cells.Bioorg Med Chem Lett. 2012 May 15;22(10):3571-4.
molnova catalog
related products
-
Rheb inhibitor NR1
Rheb inhibitor NR1 is a selective mTORC1 inhibitor that suppresses the phosphorylation of T389pS6K1 and enhances the phosphorylation of S473pAKT.
-
SPI--112Me
SPI--112Me
-
AZD 3147
AZD 3147 is an inhibitor of mTORC with IC50s of 40.7 and 5.75 nM for mTORC1 and mTORC2. AZD 3147 shows IC50s of 912, 5495, 9333, and 6310 nM for PI3Kα, PI3Kβ, PI3Kδ, and PI3Kγ, respectively.
