LDC1267( LDC1267 | LDC-1267 | LDC 1267 )

Catalog No. M17256 CAS No. 1361030-48-9

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Datasheet

HNMR

HPLC

MSDS

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Product Name

LDC1267
Note

Research use only, not for human use.
Brief Description

LDC1267 is a excellently specific TAM(Tyro3, Axl and Mer) kinase inhibitor, for Mer( IC50<5 nM), Tyro3(IC50=8 nM), and Axl(IC50=29 nM).
Description

LDC1267 is a potent and selective TAM kinase inhibitor. LDC1267 displays lower activity against Met, Aurora B, Lck, Src, and CDK8. LDC1267 markedly reduced murine mammary cancer and melanoma metastases dependent on NK cells. The TAM tyrosine kinase receptors Tyro3, Axl and Mer (also known as Mertk) were identified as ubiquitylation substrates for Cbl-b. Treatment of wild-type NK cells with a newly developed small molecule TAM kinase inhibitor conferred therapeutic potential, efficiently enhancing anti-metastatic NK cell activity in vivo.
In Vitro

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In Vivo

Animal Model:C57BL/6J wild type mice (8-12 weeks old syngeneic bearing B16F10 cells) Dosage:20mg/kg Administration:Intraperitoneal injection; every 12 hours for 14 daysResult:Markedly reduced metastatic spreading of melanomas.
Synonyms

LDC1267 | LDC-1267 | LDC 1267
Pathway

Cell Cycle/DNA Damage
Target

PLK
Recptor

AXL| Mer| Tyro3
Research Area

Inflammation/Immunology
Indication

——

CAS Number

1361030-48-9
Formula Weight

560.55
Molecular Formula

C30H26F2N4O5
Purity

>98% (HPLC)
Solubility

DMSO : 50 mg/mL. 89.20 mM; H2O : < 0.1 mg/mL
SMILES

c1(c(cc2c(c1)c(ccn2)Oc1ccc(cc1F)NC(=O)c1nn(cc1OCC)c1ccc(cc1C)F)OC)OC
Chemical Name

N-[4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-fluoro-phenyl]-4-ethoxy-1-(4-fluoro-2-methyl-phenyl)pyrazole-3-carboxamide

1. Paolino M, et al. Nature. 2014, 507(7493), 508-512.

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