Protopine( Protopine | Biflorine | Fumarine | Corydinine )

Catalog No. M17242 CAS No. 130-86-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Protopine
Note

Research use only, not for human use.
Brief Description

Protopine is a benzylisoquinoline alkaloid. It has been found to inhibit histamine H1 receptors and platelet aggregation, and acts as an analgesic.
Description

Protopine is discontinued (controlled substance). Protopine is a benzylisoquinoline alkaloid occurring in opium poppy, Corydalis tubers and other plants of the family papaveraceae, like Fumaria officinalis. It has been found to inhibit histamine H1 receptors and platelet aggregation, and acts as an analgesic.
In Vitro

Western Blot Analysis WB Cell Line:HepG2, Huh7 Concentration:10, 20, 40 μM Incubation Time:24 h Result:Induced the cleavage of caspase-3 and caspase-9.Decreased Bcl-2 and Bcl-xl level.Induced the release of mitochondrial protein cytochrome c into the cytosol.
In Vivo

Animal Model:5-hydroxy-DL-tryptophan (5-HTP)-induced mice modelDosage:5, 10, 20 mg/kg Administration:i.p.Result:Increased the number of 5-HTP-induced head twitch response (HTR).Decreased the immobility time tested in the Tail suspension test (TST).
Synonyms

Protopine | Biflorine | Fumarine | Corydinine
Pathway

PI3K/Akt/mTOR signaling
Target

mTOR
Recptor

H1 receptor| platelet aggregation
Research Area

Others-Field
Indication

——

1. Saeed SA, et al. Pharmacol Res. 1997 Jul;36(1):1-7.

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