VS-5584( VS5584 | VS 5584 | VS5584 | SB2343 )

Catalog No. M17218 CAS No. 1246560-33-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

VS-5584
Note

Research use only, not for human use.
Brief Description

VS-5584 is a pan-PI3K/mTOR kinase inhibitor.
Description

VS-5584, also known as SB2343, is a potent and selective inhibitor of both phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) kinase in the PI3K/mTOR signaling pathway, with potential antineoplastic activity. PI3K/mTOR kinase inhibitor VS-5584 inhibits mTOR kinase and all class I PI3K isoforms. Consequently, this disrupts phosphorylation of substrates downstream of PI3K and mTOR and may result in apoptosis and growth inhibition in susceptible tumor cells. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy.
In Vitro

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In Vivo

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Synonyms

VS5584 | VS 5584 | VS5584 | SB2343
Pathway

Immunology/Inflammation
Target

Amino Acids and Derivatives
Recptor

mTOR| PI3Kα| PI3Kβ| PI3Kγ| PI3Kδ
Research Area

Cancer
Indication

——

CAS Number

1246560-33-7
Formula Weight

354.41
Molecular Formula

C17H22N8O
Purity

>98% (HPLC)
Solubility

DMSO : 33.33 mg/mL. 94.04 mM;
SMILES

CC(C)n1c(C)nc2c1nc(nc2c1cnc(N)nc1)N1CCOCC1
Chemical Name

5-(9-isopropyl-8-methyl-2-morpholino-9H-purin-6-yl)pyrimidin-2-amine

1. JA Pachter, et al. Molecular Targets and Cancer Therapeutics, 2012, abstract 405.

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