WAY-100635 Maleate( WAY 100635 | WAY-100635 | WAY100635 Maleate )

Catalog No. M17140 CAS No. 1092679-51-0

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Datasheet

HNMR

HPLC

MSDS

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Product Name

WAY-100635 Maleate
Note

Research use only, not for human use.
Brief Description

WAY-100635 is a specific and effective 5-HT receptor antagonist (IC50=0.95 nM).
Description

WAY100635 Maleate is a potent, silent antagonist of serotonin 5-HT1A receptors.
In Vitro

The functional properties and binding affinities of WAY-100635 are evaluated in HEK 293 cells stably expressing dopamine D2L or D4.4 receptors.WAY-100635 displays 940, 370, and 16 nM binding affinities at D2L, D3, and D4.2 receptors, respectively. Saturation analyses demonstrat that the Kd of [3H] WAY-100635 at D4.2 receptors is 2.4 nM. WAY-100635 is potent agonist in HEK-D4.4 cells with EC50 of 9.7 nM. WAY-100635 possesses high affinity for D4.4 receptor (3.3 nM) .
In Vivo

WAY-100635 (1 mg/kg; subcutaneous injection; male Sprague-Dawley rats) treatment abolishes the reduction of the severity of abstinence signs induced by Rhodiola rosea administration in nicotine-dependent rat. Animal Model:Male Sprague-Dawley rats (220-240 g)Dosage:1 mg/kg Administration:Subcutaneous injection (Pharmacokinetic study)Result:Reduced total abstinence score, increased immobility time and the burying behavior was increased.
Synonyms

WAY 100635 | WAY-100635 | WAY100635 Maleate
Pathway

Others
Target

Other Targets
Recptor

5-HT
Research Area

Neurological Disease
Indication

——

CAS Number

1092679-51-0
Formula Weight

538.64
Molecular Formula

C25H34N4O2·C4H4O4
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 250 mg/mL 464.13 mM H2O : 25 mg/mL46.41 mM
SMILES

O=C(O)/C=C\C(=O)O.COc4ccccc4N3CCN(CCN(c1ccccn1)C(=O)C2CCCCC2)CC3
Chemical Name

N-(2-(4-(2-Methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide Maleate

1. Corradetti R, et al. J Pharmacol Exp Ther. 1996, 278(2), 679-688.

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