FIN56( FIN56 | FIN-56 | FIN 56 )

Catalog No. M17139 CAS No. 1083162-61-1

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

FIN56
Note

Research use only, not for human use.
Brief Description

FIN56 is a specific inducer of ferroptosis.
Description

FIN56 is a specific inducer of ferroptosis.
In Vitro

FIN56 (5 μM) can trigger ferroptosis by inhibition of glutathione peroxidase 4 (GPX4).FIN56 (5 μM, 10 hours) depletes GPX4 protein in HT-1080 cells.Cell Viability Assay Cell Line:TP53+/+ and TP53-/- HCT116 cells Concentration:5 μM Incubation Time:Result:Triggered ferroptosis.Western Blot Analysis Cell Line:HT-1080 cells Concentration:5 μM Incubation Time:10 hours Result:Caused a large decrease in the abundance of GPX4 at the protein level.
In Vivo

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Synonyms

FIN56 | FIN-56 | FIN 56
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

Metabolic Disease
Indication

——

CAS Number

1083162-61-1
Formula Weight

517.66
Molecular Formula

C25H31N3O5S2
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 100 mg/mL 193.18 mM H2O : < 0.1 mg/mL
SMILES

C1CCC(CC1)NS(=O)(=O)C2=CC3=C(C=C2)C4=C(C3=NO)C=C(C=C4)S(=O)(=O)NC5CCCCC5
Chemical Name

N2,N7-Dicyclohexyl-9-(hydroxyimino)-9H-fluorene-2,7-disulfonamide

1. Shimada K, et al. Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis. Nat Chem Biol. 2016 Jul;12(7):497-503.

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