AT-406 HCl( —— )

Catalog No. M17137 CAS No. 1071992-57-8

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HNMR

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Product Name

AT-406 HCl
Note

Research use only, not for human use.
Brief Description

AT-406, an orally active antagonist of multiple inhibitor of apoptosis proteins(IAP).
Description

AT-406, an orally active antagonist of multiple inhibitor of apoptosis proteins(IAP), inhibits progression of human ovarian Y binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, 50- to 100-fold higher affinities than the Smac AVPI peptide.
In Vitro

Xevinapant (AT-406) hydrochloride potently inhibits cell growth in the MDA-MB-231 breast and SK-OV-3 ovarian cancer cell lines with IC50=144 nM and 142 nM, respectively.Xevinapant (0-3 μM; 0-48 horus) hydrochloride effectively induces cell death in a time- and dose-dependent manner.
In Vivo

Xevinapant (AT-406) hydrochloride is very effective in inhibition of tumor growth in the MDA-MB-231 xenograft model, and has minimal toxicity to animals. Xevinapant hydrochloride evaluated for its pharmacokinetic (PK) properties in mice, rats, non-human primates and dogs. Animal Model:SCID mice bearing MDA-MB-231 xenograft tumors Dosage:30 and 100 mg/kg Administration:p.o.; 5 days a week for 2 weeks Result:Strongly inhibits tumor growth at 30 and 100 mg/kg and completely inhibits tumor growth during the treatment with 100 mg/kg.
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Apoptosis protein
Research Area

——
Indication

——

CAS Number

1071992-57-8
Formula Weight

598.19
Molecular Formula

C32H44ClN5O4
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 175 mg/mL (292.55 mM)
SMILES

N12[C@@H](CCN(C[C@@H](C1=O)NC(=O)[C@H](C)NC)C(=O)CC(C)C)CC[C@H]2C(=O)NC(c1ccccc1)c1ccccc1
Chemical Name

——

1. Melissa KB, et al. Y Biol Ther. 2012 Jul 1; 13(9): 804–811.

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