Cabotegravir( S/GSK1265744 | GSK 744 | Cabotegravir )

Catalog No. M17126 CAS No. 1051375-10-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Cabotegravir
Note

Research use only, not for human use.
Brief Description

Cabotegravir (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor and inhibits the HIV-1 integrase catalyzed strand transfer reaction (IC50: 3.0 nM).
Description

Cabotegravir, also known as S/GSK1265744 or GSK744, is potent HIV integrase inhibitor under development for the treatment of HIV infection. Cabotegravir has a carbamoyl pyridone structure similar to dolutegravir.
In Vitro

Cell Viability Assay Cell Line:MT-4 cells Concentration:0-32 nM Incubation Time:4 or 5 days Result:Showed antiviral activity with an EC50 of 1.3 nM.
In Vivo

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Synonyms

S/GSK1265744 | GSK 744 | Cabotegravir
Pathway

Others
Target

Other Targets
Recptor

HIV integrase
Research Area

Infection
Indication

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CAS Number

1051375-10-0
Formula Weight

405.35
Molecular Formula

C19H17F2N3O5
Purity

>98% (HPLC)
Solubility

DMSO : 12.67 mg/mL 31.26 mM;
SMILES

C[C@H]1CO[C@H]2N1C(=O)c1c(c(=O)c(cn1C2)C(=O)NCc1c(cc(cc1)F)F)O
Chemical Name

(3S,11aR)-N-(2,4-difluorobenzyl)-6-hydroxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydrooxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide

1. Yoshinaga T, et al. Antimicrob Agents ChemOthers. 2015, 59(1), 397-406.

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