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Sematilide HCl
CAS No. 101526-62-9
Sematilide HCl( —— )
Catalog No. M17117 CAS No. 101526-62-9
Sematilide (CK-1752) is a class III antiarrhythmic. It is a selectively delayed rectifier K+ current (IKr) channel blocker.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 48 | In Stock |
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| 5MG | 41 | In Stock |
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| 10MG | 65 | In Stock |
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| 25MG | 130 | In Stock |
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| 50MG | 207 | In Stock |
|
| 100MG | 333 | In Stock |
|
| 200MG | 462 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSematilide HCl
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NoteResearch use only, not for human use.
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Brief DescriptionSematilide (CK-1752) is a class III antiarrhythmic. It is a selectively delayed rectifier K+ current (IKr) channel blocker.
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DescriptionSematilide (CK-1752) is a class III antiarrhythmic. It is a selectively delayed rectifier K+ current (IKr) channel blocker. It inhibits rapidly activating Ik in guinea pig atrial myocytes, resulting in the prolongation of refractoriness and action potential duration.
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In VitroApplication of 10, 30, 100 and 300 μM Sematilide causes a concentration-dependent inhibition of the delayed rectifier K+ current (IC50=25 μM).
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In VivoSematilide (0.3-1.0 mg/kg, intravenously i.v.) is effective in a canine model of arrhythmia. Animal Model:Mongrel dogs of either sex (10-18 kg body weight) Dosage:0.3, 1, 3, and 10 mg/kg Administration:I.v. infusions Result:Demonstrated antiarrhythmic effects at 0.3 and 3.0 mg/kg.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorK+ current (IKr) channel
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Research Area——
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Indication——
Chemical Information
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CAS Number101526-62-9
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Formula Weight349.87
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Molecular FormulaC14H24ClN3O3S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?H2O : 5 mg/mL (14.29 mM)
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SMILESCCN(CC)CCNC(=O)c1ccc(cc1)NS(=O)(=O)C.Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Yoshida H,et al. Circ J. 2002 Aug;66(8):758-62.
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