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Sematilide HCl

CAS No. 101526-62-9

Sematilide HCl( —— )

Catalog No. M17117 CAS No. 101526-62-9

Sematilide (CK-1752) is a class III antiarrhythmic. It is a selectively delayed rectifier K+ current (IKr) channel blocker.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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1 mL x 10 mM in DMSO 48 In Stock
5MG 41 In Stock
10MG 65 In Stock
25MG 130 In Stock
50MG 207 In Stock
100MG 333 In Stock
200MG 462 In Stock
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Biological Information

  • Product Name
    Sematilide HCl
  • Note
    Research use only, not for human use.
  • Brief Description
    Sematilide (CK-1752) is a class III antiarrhythmic. It is a selectively delayed rectifier K+ current (IKr) channel blocker.
  • Description
    Sematilide (CK-1752) is a class III antiarrhythmic. It is a selectively delayed rectifier K+ current (IKr) channel blocker. It inhibits rapidly activating Ik in guinea pig atrial myocytes, resulting in the prolongation of refractoriness and action potential duration.
  • In Vitro
    Application of 10, 30, 100 and 300 μM Sematilide causes a concentration-dependent inhibition of the delayed rectifier K+ current (IC50=25 μM).
  • In Vivo
    Sematilide (0.3-1.0 mg/kg, intravenously i.v.) is effective in a canine model of arrhythmia. Animal Model:Mongrel dogs of either sex (10-18 kg body weight) Dosage:0.3, 1, 3, and 10 mg/kg Administration:I.v. infusions Result:Demonstrated antiarrhythmic effects at 0.3 and 3.0 mg/kg.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    K+ current (IKr) channel
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    101526-62-9
  • Formula Weight
    349.87
  • Molecular Formula
    C14H24ClN3O3S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?H2O : 5 mg/mL (14.29 mM)
  • SMILES
    CCN(CC)CCNC(=O)c1ccc(cc1)NS(=O)(=O)C.Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Yoshida H,et al. Circ J. 2002 Aug;66(8):758-62.
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