Sematilide HCl( —— )

Catalog No. M17117 CAS No. 101526-62-9

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Product Name

Sematilide HCl
Note

Research use only, not for human use.
Brief Description

Sematilide (CK-1752) is a class III antiarrhythmic. It is a selectively delayed rectifier K+ current (IKr) channel blocker.
Description

Sematilide (CK-1752) is a class III antiarrhythmic. It is a selectively delayed rectifier K+ current (IKr) channel blocker. It inhibits rapidly activating Ik in guinea pig atrial myocytes, resulting in the prolongation of refractoriness and action potential duration.
In Vitro

Application of 10, 30, 100 and 300 μM Sematilide causes a concentration-dependent inhibition of the delayed rectifier K+ current (IC50=25 μM).
In Vivo

Sematilide (0.3-1.0 mg/kg, intravenously i.v.) is effective in a canine model of arrhythmia. Animal Model:Mongrel dogs of either sex (10-18 kg body weight) Dosage:0.3, 1, 3, and 10 mg/kg Administration:I.v. infusions Result:Demonstrated antiarrhythmic effects at 0.3 and 3.0 mg/kg.
Synonyms

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Pathway

Others
Target

Other Targets
Recptor

K+ current (IKr) channel
Research Area

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Indication

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1. Yoshida H,et al. Circ J. 2002 Aug;66(8):758-62.

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