SALL4 peptide FFW( RRKFAKFQWI | FFW peptide )

Catalog No. M17053 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

SALL4 peptide FFW
Note

Research use only, not for human use.
Brief Description

SALL4 peptide FFW (RRKFAKFQWI, FFW peptide) is a potent therapeutic SALL4 peptide antagonist of SALL4-NURD.
Description

SALL4 peptide FFW (RRKFAKFQWI, FFW peptide) is a potent therapeutic SALL4 peptide antagonist of SALL4-NURD (nucleosome remodeling deacetylase) interaction with target affinity of 23 nM; reverses Transcription Repression by SALL4-RBBp4, disrupts the SALL4-NuRD complex resulted in unidirectional up-regulation of transcripts, turning SALL4 from a dual transcription repressor-activator mode to singular transcription activator mode; displays significant antitumor effects, inhibiting tumor growth by 85% in xenograft mouse models of HCC.
In Vitro

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In Vivo

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Synonyms

RRKFAKFQWI | FFW peptide
Pathway

Cell Cycle/DNA Damage
Target

HDAC
Recptor

HDAC
Research Area

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Indication

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1. Liu BH, et al. Proc Natl Acad Sci U S A. 2018 Jul 5. pii: 201801253.

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