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ZLc002
CAS No. ——
ZLc002( ZLc-002 | ZLc 002 )
Catalog No. M17030 CAS No. ——
ZLc002 (ZLc-002) is a putative small-molecule inhibitor of nNOS interaction with NOS1AP.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameZLc002
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NoteResearch use only, not for human use.
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Brief DescriptionZLc002 (ZLc-002) is a putative small-molecule inhibitor of nNOS interaction with NOS1AP.
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DescriptionZLc002 (ZLc-002) is a putative small-molecule inhibitor of nNOS interaction with NOS1AP, disrupts neuronal nitric oxide synthase-NOS1AP interaction in intact cells; exhibits anxiolytic-like efficacy in a mouse model of chronic mild stress without altering appetite, general activity, or locomotor activity or interfering with the resting potential of neurons, also inhibits co-immunoprecipitation of NOS1AP with nNOS in hippocampal cells; suppresses inflammatory nociception and chemotherapy-induced neuropathic pain and synergizes with paclitaxel to reduce tumor cell viability; suppresses formalin-evoked inflammatory pain in rats and reduced Fos protein-like immunoreactivity in the lumbar spinal dorsal horn (4-10 mg/kg i.p.).
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In Vitro——
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In Vivo——
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SynonymsZLc-002 | ZLc 002
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PathwayImmunology/Inflammation
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TargetNOS
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RecptorNOS
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Research Area——
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Indication——
Chemical Information
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CAS Number——
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Formula Weight229.276
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Molecular FormulaC11H19NO4
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical NameMethyl 3-((2-methyl-4-oxohexan-3-yl)amino)-3-oxopropanoate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lee WH, et al. Mol Pain. 2018 Jan-Dec;14:1744806918801224.
2. Zhu LJ, et al. Nat Med. 2014 Sep;20(9):1050-4.
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