ZLc002

Research use only, not for human use.

ZLc002 (ZLc-002) is a putative small-molecule inhibitor of nNOS interaction with NOS1AP.

ZLc002 (ZLc-002) is a putative small-molecule inhibitor of nNOS interaction with NOS1AP, disrupts neuronal nitric oxide synthase-NOS1AP interaction in intact cells; exhibits anxiolytic-like efficacy in a mouse model of chronic mild stress without altering appetite, general activity, or locomotor activity or interfering with the resting potential of neurons, also inhibits co-immunoprecipitation of NOS1AP with nNOS in hippocampal cells; suppresses inflammatory nociception and chemotherapy-induced neuropathic pain and synergizes with paclitaxel to reduce tumor cell viability; suppresses formalin-evoked inflammatory pain in rats and reduced Fos protein-like immunoreactivity in the lumbar spinal dorsal horn (4-10 mg/kg i.p.).

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ZLc-002 | ZLc 002

Immunology/Inflammation

NOS

NOS

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229.276

C11H19NO4

>98% (HPLC)

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Methyl 3-((2-methyl-4-oxohexan-3-yl)amino)-3-oxopropanoate

(-20℃)

With Ice Pack

≥ 2 years