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Pim inhibitor 28
CAS No. ——
Pim inhibitor 28( —— )
Catalog No. M17026 CAS No. ——
Pim inhibitor 28 is a potent, selective inhibitor of Pim1/2 with IC50 of 0.05 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NamePim inhibitor 28
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NoteResearch use only, not for human use.
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Brief DescriptionPim inhibitor 28 is a potent, selective inhibitor of Pim1/2 with IC50 of 0.05 nM.
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DescriptionPim inhibitor 28 is a potent, selective inhibitor of Pim1/2 with IC50 of 0.05 nM for both, demonstrates on-target Pim activity in an in vivo pharmacodynamic assay with significant inhibition of BAD phosphorylation in KMS-12-BM multiple myeloma tumors.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayJAK/STAT Signaling
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TargetPim
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RecptorPim
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Research Area——
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Indication——
Chemical Information
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CAS Number——
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Formula Weight403.486
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Molecular FormulaC23H25N5O2
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name(R)-8-(6-Methyl-4-oxo-1,4,5,6-tetrahydropyrrolo[3,4-b]pyrrol-2-yl)-3-(1-methylcyclopropyl)-2-((1-methylcyclopropyl)amino)quinazolin-4(3H)-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wang HL, et al. J Med Chem. 2019 Jan 9. doi: 10.1021/acs.jmedchem.8b01733.
molnova catalog
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