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MKK7-COV-9
CAS No. ——
MKK7-COV-9( MKK7 Covalen inhibitor 9 )
Catalog No. M16996 CAS No. ——
MKK7-COV-9 (MKK7 Covalen inhibitor 9) is a potent, selective, covalent MKK7 inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameMKK7-COV-9
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NoteResearch use only, not for human use.
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Brief DescriptionMKK7-COV-9 (MKK7 Covalen inhibitor 9) is a potent, selective, covalent MKK7 inhibitor.
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DescriptionMKK7-COV-9 (MKK7 Covalen inhibitor 9) is a potent, selective, covalent MKK7 inhibitor, displays >1,000-fold selectivity over MKK4; displays remarkable selectivity against a kinome panel of 76 kinases; inhibits the CD86+ response in primary mouse B cells in response to LPS stimulation (EC50=4.9 uM); has half-lives >40 min in dog and rat, and significantly improved stability in human and monkey liver microsomes; MKK7-COV-9 is not cytotoxic to a panel of human cell lines.
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In Vitro——
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In Vivo——
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SynonymsMKK7 Covalen inhibitor 9
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PathwayMAPK/ERK Signaling
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TargetMEK
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RecptorMEK
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Research Area——
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Indication——
Chemical Information
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CAS Number——
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Formula Weight320.352
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Molecular FormulaC18H16N4O2
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name3-acrylamido-5-(1H-indazol-3-yl)-N-methylbenzamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Shraga A, et al. Cell Chem Biol. 2018 Oct 24. pii: S2451-9456(18)30344-1.
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