RAS inhibitor Abd-7

Research use only, not for human use.

RAS inhibitor Abd-7 is a potent RAS-binding compound (Kd=51 nM) that interacts with RAS in cells.

RAS inhibitor Abd-7 is a potent RAS-binding compound (Kd=51 nM) that interacts with RAS in cells, prevents RAS-effector interactions and inhibits endogenous RAS-dependent signalling; impairs the protein-protein interaction (PPI) of various mutant KRAS proteins with PI3K, CRAF and RALGDS as well as NRASQ61H and HRASG12V, inhibits phosphorylation of both downstream biomarkers in colorectal cancer (DLD-1, KRASG13D) and NSCLC (H538, KRASG12C) human cell lines, with reduction of AKT phosphorylation starting at 2 uM; shows consistent inhibitory effects in the cell-based BRET assay and the biomarker assay.

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MAPK/ERK Signaling

Ras

Ras

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391.471

C23H25N3O3

>98% (HPLC)

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6-(2,3-dihydrobenzo[b][1,4]dioxin-5-yl)-N-(4-((dimethylamino)methyl)phenyl)-2-methoxypyridin-3-amine

(-20℃)

With Ice Pack

≥ 2 years