JNJ-28312141 hydrochloride( JNJ28312141 )

Catalog No. M16981 CAS No. ——

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Product Name

JNJ-28312141 hydrochloride
Note

Research use only, not for human use.
Brief Description

JNJ-28312141 is a potent, orally active CSF-1 receptor (CSF-1R) kinase inhibitor with IC50 of 0.69 nM.
Description

JNJ-28312141 is a potent, orally active CSF-1 receptor (CSF-1R) kinase inhibitor with IC50 of 0.69 nM; shows narrow kinase selectivity profile, also potently inhibits KIT (IC50=5 nM), AXL (12 nM), TRKA (15 nM), FLT3 (30 nM), and LCK (88 nM); inhibits CSF-1-induced CSF-1R phosphorylation with IC50 of 5 nM, inhibits CSF-1-dependent proliferation of mouse macrophages and CSF-1-induced expression of MCP-1 by human monocytes with IC50 of 3 nM; inhibits the ITD-FLT3-dependent proliferation of MV-4-11 cells with IC50 of 21 nM, inhibits FLT3 ligand-induced FLT3 phosphorylation in recombinant Baf3 cells with IC50 of 76 nM; demonstrates potential therapeutic activity in AML, solid tumors and bone metastases in vivo.
In Vitro

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In Vivo

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Synonyms

JNJ28312141
Pathway

Tyrosine Kinase
Target

CSF1R
Recptor

CSF1R
Research Area

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Indication

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CAS Number

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Formula Weight

497.04
Molecular Formula

C26H33ClN6O2
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

4-cyano-N-(5-(1-(2-(dimethylamino)acetyl)piperidin-4-yl)-2',3',4',5'-tetrahydro-[1,1'-biphenyl]-2-yl)-1H-imidazole-2-carboxamide hydrochloride

1. Manthey CL, et al. Mol Cancer Ther. 2009 Nov;8(11):3151-61. 2. Illig CR, et al. J Med Chem. 2011 Nov 24;54(22):7860-83.

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