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FMF-04-159-2
CAS No. ——
FMF-04-159-2( —— )
Catalog No. M16940 CAS No. ——
FMF-04-159-2 is a potent, selective, covalent CDK14 inhibitor (IC50=86 nM) with pan-TAIRE family specificity (CDKs 14-18).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameFMF-04-159-2
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NoteResearch use only, not for human use.
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Brief DescriptionFMF-04-159-2 is a potent, selective, covalent CDK14 inhibitor (IC50=86 nM) with pan-TAIRE family specificity (CDKs 14-18).
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DescriptionFMF-04-159-2 is a potent, selective, covalent CDK14 inhibitor (IC50=86 nM) with pan-TAIRE family specificity (CDKs 14-18); potently inhibited the TAIRE kinases CDK14, CDK16, CDK17, and CDK18; CDK14 was potently engaged by FMF-04-159-2 (IC50=39.6 nM), and this engagement was sustained after a 2-h, compound washout (IC50=56.3 nM), indicates irreversible binding; FMF-04-159-2 is a valuable tool for study of CDK14 kinase function.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetCDK
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RecptorCDK
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Research Area——
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Indication——
Chemical Information
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CAS Number——
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Formula Weight683.002
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Molecular FormulaC28H30Cl3N7O5S
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name(E)-N-(1-((3-(4-(dimethylamino)but-2-enamido)phenyl)sulfonyl)piperidin-4-yl)-4-(2,4,6-trichlorobenzamido)-1H-pyrazole-3-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ferguson FM, et al. Cell Chem Biol. 2019 Mar 11. pii: S2451-9456(19)30070-4.
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