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SCF-I2
CAS No. 99827-46-0
SCF-I2( SCF I2 )
Catalog No. M16917 CAS No. 99827-46-0
An allosteric, sepecific inhibitor of substrate recognition by the SCFCdc4 ubiquitin ligase with IC50 of 6.2 uM in FP assyas.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameSCF-I2
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NoteResearch use only, not for human use.
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Brief DescriptionAn allosteric, sepecific inhibitor of substrate recognition by the SCFCdc4 ubiquitin ligase with IC50 of 6.2 uM in FP assyas.
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DescriptionAn allosteric, sepecific inhibitor of substrate recognition by the SCFCdc4 ubiquitin ligase with IC50 of 6.2 uM in FP assyas; does not affect the activity of the closely related E3 enzyme SCFMet30, inhibits binding and/or ubiquitination of both full length Sic1 and Far1 with IC50 of 60 uM.
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In Vitro——
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In Vivo——
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SynonymsSCF I2
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PathwayProteasome/Ubiquitin
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TargetE3 Ubiquitin Ligase
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RecptorE3 Ubiquitin Ligase
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Research Area——
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Indication——
Chemical Information
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CAS Number99827-46-0
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Formula Weight342.35
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Molecular Formula22H14O4
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Purity>98% (HPLC)
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Solubility——
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SMILESC1=CC=C2C(=C1)C=CC(=C2C3=C(C=CC4=CC=CC=C43)C(=O)O)C(=O)O
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Chemical Name1-(2-carboxynaphth-1yl)-2-naphthoic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Orlicky S, et al. Nat Biotechnol. 2010 Jul;28(7):733-7.
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