Rotigotine

CAS No. 99755-59-6

Rotigotine( N-0923 | SPM 962 )

Catalog No. M16916 CAS No. 99755-59-6

A non-selective agonist of the dopamine D3 receptor (Ki=0.71 nM); has 10-fold selectivity for the D3 receptor over the D2, D4, and D5 receptors and 100-fold selectivity for the D3 receptor over the D1 receptor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 48 In Stock
5MG 46 In Stock
10MG 67 In Stock
25MG 141 In Stock
50MG 249 In Stock
100MG 369 In Stock
200MG 541 In Stock
500MG 849 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Rotigotine
  • Note
    Research use only, not for human use.
  • Brief Description
    A non-selective agonist of the dopamine D3 receptor (Ki=0.71 nM); has 10-fold selectivity for the D3 receptor over the D2, D4, and D5 receptors and 100-fold selectivity for the D3 receptor over the D1 receptor.
  • Description
    A non-selective agonist of the dopamine D3 receptor (Ki=0.71 nM); has 10-fold selectivity for the D3 receptor over the D2, D4, and D5 receptors and 100-fold selectivity for the D3 receptor over the D1 receptor; behaves as a full agonist of D1, D2, and D3 with similar potencies (EC50) in functional assay; also demonstrates significant affinity at α-adrenergic (α2B, Ki=27 nM) and serotonin receptors (5-HT1A Ki=30 nM); significantly attenuates MPTP-induced acute cell degeneration in mouse model.Parkinson's Disease Approved(In Vitro):Rotigotine (0.01-10 μM) slightly protects dopaminergic neurons against MPP+ toxicity dopamine, protects dopaminergic neurons against rotenone-induced cell death and significantly inhibits ROS production by rotenone.(In Vivo):Rotigotine (0.1-5 mg/kg; i.h.; for 14 days; male Sprague–Dawley rats) has antidepressant effect.
  • In Vitro
    Rotigotine (0.01-10 μM) slightly protects dopaminergic neurons against MPP+ toxicity dopamine, protects dopaminergic neurons against rotenone-induced cell death and significantly inhibits ROS production by rotenone.
  • In Vivo
    Rotigotine (0.1-5 mg/kg; i.h.; for 14 days; male Sprague–Dawley rats) has antidepressant effect. Animal Model:Male Sprague–Dawley rats Dosage:0.1, 0.5, 1, and 5 mg/kg Administration:Subcutaneous injection; for 14 days.Result:Had antidepressant effect at a dose of 1 mg/kg or less.
  • Synonyms
    N-0923 | SPM 962
  • Pathway
    GPCR/G Protein
  • Target
    Dopamine Receptor
  • Recptor
    D2|D3
  • Research Area
    Neurological Disease
  • Indication
    Parkinson Disease

Chemical Information

  • CAS Number
    99755-59-6
  • Formula Weight
    315.4729
  • Molecular Formula
    C19H25NOS
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    CCCN(CCC1=CC=CS1)C2CCC3=C(C2)C=CC=C3O
  • Chemical Name
    1-Naphthalenol, 5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-, (6S)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wood M, et al. Br J Pharmacol. 2015 Feb;172(4):1124-35. 2. Scheller D, et al. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan;379(1):73-86. 3. Scheller D, et al. Neurosci Lett. 2008 Feb 13;432(1):30-4.
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