Topiramate

Research use only, not for human use.

Topiramate (brand name Topamax) is an anticonvulsant drug produced by Ortho-McNeil Neurologics.

Topiramate (brand name Topamax) is an anticonvulsant drug produced by Ortho-McNeil Neurologics, a division of Johnson & Johnson. It is used to treat epilepsy in both children and adults. In children it is also indicated for treatment of Lennox-Gastaut syndrome (a disorder that causes seizures and developmental delays). It is also Food and Drug Administration (FDA) approved for, and now most frequently prescribed for, the prevention of migraines. A combination product containing phentermine and topiramate extended-release called QSYMIA is indicated for the management of obesity. (In Vitro):Topiramate has been believed to be a type of antiepileptic drug that blocks spread of seizures. Thus far, the mechanisms of its actions have been proven to include use-dependent inhibition of voltage-dependent Na+ channels in neurons, potentiation of GABA (γ-amino-butyric acid)-induced Cl- influx, and inhibitory effects on inward currents by antagonizing kainate/alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors.

Topiramate has been believed to be a type of antiepileptic drug that blocks spread of seizures. Thus far, the mechanisms of its actions have been proven to include use-dependent inhibition of voltage-dependent Na+ channels in neurons, potentiation of GABA (γ-amino-butyric acid)-induced Cl- influx, and inhibitory effects on inward currents by antagonizing kainate/alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors.

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McN 4853 | RWJ 17021 | TPM

Membrane Transporter/Ion Channel

Carbonic Anhydrase

Carbonic anhydrase| GABAR| mGluR5

Neurological Disease

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97240-79-4

339.36

C12H21NO8S

>98% (HPLC)

Ethanol: 68 mg/mL (200.37 mM); DMSO: 68 mg/mL (200.37 mM)

CC1(O[C@H]([C@@H](CO[C@@]2(COS(=O)(N)=O)O3)O1)[C@@H]2OC3(C)C)C

((3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4',5'-d]pyran-3a-yl)methyl sulfamate

(-20℃)

With Ice Pack

≥ 2 years