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Elubrixin tosylate

CAS No. 960495-43-6

Elubrixin tosylate( SB-656933 )

Catalog No. M16860 CAS No. 960495-43-6

Elubrixin (SB-656933) is a potent, selective, competitive and reversible CXCR2 antagonist.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Elubrixin tosylate
  • Note
    Research use only, not for human use.
  • Brief Description
    Elubrixin (SB-656933) is a potent, selective, competitive and reversible CXCR2 antagonist.
  • Description
    Elubrixin (SB-656933) is a potent, selective, competitive and reversible CXCR2 antagonist; inhibits CXCL1-induced CD11b up-regulation on PMNs in an in vitro whole blood assay and to be active in in vivo rodent inhalation challenge models of airway inflammation that used endotoxin and ozone to induce airway neutrophilia.Fibrosis Phase 2 Discontinued.
  • In Vitro
    Elubrixin has an inhibitory effect on neutrophils in a dose-dependent fashion.
  • In Vivo
    ——
  • Synonyms
    SB-656933
  • Pathway
    GPCR/G Protein
  • Target
    Chemokine Receptor
  • Recptor
    Chemokine Receptor
  • Research Area
    Other Indications
  • Indication
    Fibrosis

Chemical Information

  • CAS Number
    960495-43-6
  • Formula Weight
    635.503
  • Molecular Formula
    C24H25Cl2FN4O7S2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (196.69 mM)
  • SMILES
    CC1=CC=C(C=C1)S(=O)(=O)O.C1CN(CCN1)S(=O)(=O)C2=C(C=CC(=C2O)NC(=O)NC3=C(C(=CC=C3)F)Cl)Cl
  • Chemical Name
    1-(2-chloro-3-fluorophenyl)-3-(4-chloro-2-hydroxy-3-piperazin-1-ylsulfonylphenyl)urea tosylate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lazaar AL, et al. Br J Clin Pharmacol. 2011 Aug;72(2):282-93. 2. Nicholson GC, et al. Pulm Pharmacol Ther. 2007;20(1):52-9. 3. Kaur M, et al. J Pharmacol Exp Ther. 2013 Oct;347(1):173-80. 4. Busch-Petersen J, et al. Curr Top Med Chem. 2006;6(13):1345-52.
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