RAF-IN-10n( B-RAF IN 1 )

Catalog No. M16798 CAS No. 950736-05-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

RAF-IN-10n
Note

Research use only, not for human use.
Brief Description

A highlt potent and selective BRAF/CRAF inhibitor with IC50 of 24/25 nM, respectively.
Description

A highlt potent and selective BRAF/CRAF inhibitor with IC50 of 24/25 nM, respectively; displays moderate selectivity over p38α (IC50=216 nM) and CAMKII (IC50=822 nM), high selectivity over CDK2, CDK4, PKCa, IKKb, JNK1, MK2, PKA, Src, MKK6, PLK1, p70S6K, PI3 Ka, and PDK1 (IC50>2 uM).
In Vitro

B-Raf IN 1 (Compound 10n) inhibits WM 266-4 and HT29 cells with IC50s of 0.92 and 0.78 μM, respectively.
In Vivo

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Synonyms

B-RAF IN 1
Pathway

MAPK/ERK Signaling
Target

Raf
Recptor

B-Raf|C-Raf
Research Area

Cancer
Indication

——

CAS Number

950736-05-7
Formula Weight

515.529
Molecular Formula

C29H24F3N5O
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 53 mg/mL
SMILES

O=C(NC1=CC=CC(C2=CC=NC3=C(C4=CC=C(CN(C)C)C=C4)C=NN23)=C1)C5=CC=CC(C(F)(F)F)=C5
Chemical Name

Benzamide, N-[3-[3-[4-[(dimethylamino)methyl]phenyl]pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]-3-(trifluoromethyl)-

1. Berger DM, et al. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6519-23.

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