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Famitinib
CAS No. 945380-27-8
Famitinib( SHR 1020 )
Catalog No. M16770 CAS No. 945380-27-8
Famitinib (SHR1020) is a structural analogue of sunitinib, novel and potent multi-targeted RTK inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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| 100MG | Get Quote | Get Quote |
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Biological Information
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Product NameFamitinib
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NoteResearch use only, not for human use.
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Brief DescriptionFamitinib (SHR1020) is a structural analogue of sunitinib, novel and potent multi-targeted RTK inhibitor.
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DescriptionFamitinib (SHR1020) is a structural analogue of sunitinib, novel and potent multi-targeted RTK inhibitor, including c-Kit, VEGFR2/3, PDGFRβ, FLT-1/3 receptor and c-RET; demonstrates the higher potency in tumour growth inhibition in human tumour xenograft models compared with sunitinib.Colon Cancer Phase 3 Clinical.
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In Vitro——
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In Vivo——
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SynonymsSHR 1020
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PathwayAngiogenesis
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Targetc-Kit
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Recptorc-Kit
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Research AreaCancer
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IndicationColon Cancer
Chemical Information
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CAS Number945380-27-8
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Formula Weight410.493
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Molecular FormulaC23H27FN4O2
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Purity>98% (HPLC)
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Solubility——
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SMILESCCN(CC)CCN1CCC2=C(C1=O)C(=C(N2)C=C3C4=C(C=CC(=C4)F)NC3=O)C
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Chemical Name(Z)-5-(2-(diethylamino)ethyl)-2-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-3-methyl-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Xie C, et al. Br J Pharmacol. 2013 Apr;168(7):1687-706.
2. Zhang W, et al. Chin Med J (Engl). 2013 Nov;126(22):4277-81.
3. Zhou A, et al. Cancer Chemother Pharmacol. 2013 Nov;72(5):1043-53.
4. Ge S, et al. Oncol Lett. 2016 Sep;12(3):1763-1768.
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