Cart
sales@molnova.com
Pimelic Diphenylamide 106
CAS No. 937039-45-7
Pimelic Diphenylamide 106( RGFA-8 | TC-H 106 | BRD-4657 )
Catalog No. M16712 CAS No. 937039-45-7
A slow, tight-binding inhibitor of class I HDACs.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 28 | In Stock |
|
| 10MG | 37 | In Stock |
|
| 25MG | 65 | In Stock |
|
| 50MG | 110 | In Stock |
|
| 100MG | 200 | In Stock |
|
| 200MG | 296 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NamePimelic Diphenylamide 106
-
NoteResearch use only, not for human use.
-
Brief DescriptionA slow, tight-binding inhibitor of class I HDACs.
-
DescriptionA slow, tight-binding inhibitor of class I HDACs (HDAC1/2/3, Ki=148/102/14 nM respectively); shows weak inhibition on HDAC8 (IC50=5 uM); has preference toward HDAC3.
-
In Vitro——
-
In Vivo——
-
SynonymsRGFA-8 | TC-H 106 | BRD-4657
-
PathwayCell Cycle/DNA Damage
-
TargetHDAC
-
RecptorHDAC
-
Research AreaNeurological Disease
-
Indication——
Chemical Information
-
CAS Number937039-45-7
-
Formula Weight339.4314
-
Molecular FormulaC20H25N3O2
-
Purity>98% (HPLC)
-
SolubilityDMSO: ≥ 25 mg/mL
-
SMILESO=C(NC1=CC=CC=C1N)CCCCCC(NC2=CC=C(C)C=C2)=O
-
Chemical NameHeptanediamide, N1-(2-aminophenyl)-N7-(4-methylphenyl)-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Chou CJ, et al. J Biol Chem. 2008 Dec 19;283(51):35402-9.
2. Xu C, et al. Chem Biol. 2009 Sep 25;16(9):980-9.
molnova catalog
related products
-
Tasquinimod
An orally active antiangiogenic agent with anti-prostate cancer activity, an allosteric modulator of HDAC4 with Kd of 10-30 nM.
-
T247
A potent and selective HDAC3 inhibitor with IC50 of 0.24 uM, >75-fold selectivity over HDAC1 and no activity against HDAC4/6/8.
-
CHR-3996
CHR-3996 (Nanatinostat, VRx-3996, CHR3996, Tractinostat) is a potent, class I-selective, orally active HDAC inhibitor with IC50 of 3-7 nM for HDAC1/2/3.
