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Vaniprevir
CAS No. 923590-37-8
Vaniprevir( MK-7009 | MK7009 | MK 7009 )
Catalog No. M16617 CAS No. 923590-37-8
A potent, selective, orally available inhibitor of HCV NS3/4A protease with Ki of 0.05 and 0.9 nM for GT1b and 2a protease, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1701 | In Stock |
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| 10MG | 2299 | In Stock |
|
| 25MG | 3420 | In Stock |
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| 50MG | 4511 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameVaniprevir
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective, orally available inhibitor of HCV NS3/4A protease with Ki of 0.05 and 0.9 nM for GT1b and 2a protease, respectively.
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DescriptionA potent, selective, orally available inhibitor of HCV NS3/4A protease with Ki of 0.05 and 0.9 nM for GT1b and 2a protease, respectively; displays excellent selectivity against both a range of human proteases and a broad panel of pharmacologically relevant targets; has replicon EC50 of 3 and 9 nM for GT1b and 2a, respectively, has good plasma exposure and excellent liver exposure in multiple species.HCV Infection Approved.
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In Vitro——
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In Vivo——
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SynonymsMK-7009 | MK7009 | MK 7009
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PathwayMicrobiology/Virology
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TargetHCV
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RecptorHCV
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Research AreaInfection
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IndicationHCV Infection
Chemical Information
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CAS Number923590-37-8
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Formula Weight757.9364
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Molecular FormulaC38H55N5O9S
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCC[C@@H]1C[C@@]1(C(NS(=O)(C2CC2)=O)=O)NC([C@@H]3C[C@@H]4CN3C([C@H](C(C)(C)C)NC(OCC(C)(CCCCC5=CC=CC6=C5CN(C(O4)=O)C6)C)=O)=O)=O
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Chemical NameCyclopropanecarboxamide, N-[[[6-(2-carboxy-2,3-dihydro-1H-isoindol-4-yl)-2,2-dimethylhexyl]oxy]carbonyl]-3-methyl-L-valyl-(4R)-4-hydroxy-L-prolyl-1-amino-N-(cyclopropylsulfonyl)-2-ethyl-, (12)-lactone, (1R,2R)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. McCauley JA, et al. J Med Chem. 2010 Mar 25;53(6):2443-63.
2. Liverton NJ, et al. Antimicrob Agents Chemother. 2010 Jan;54(1):305-11.
3. Manns MP, et al. Hepatology. 2012 Sep;56(3):884-93.
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