Cazpaullone( 9-Cyano-1-azapaullone )

Catalog No. M16568 CAS No. 914088-64-5

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Product Name

Cazpaullone
Note

Research use only, not for human use.
Brief Description

Cazpaullone (9-Cyano-1-azapaullone) is a derivative of 1-Azakenpaullone, a potent, selective GSK3β inhibitor with IC50 of 8 nM.
Description

Cazpaullone (9-Cyano-1-azapaullone) is a derivative of 1-Azakenpaullone, a potent, selective GSK3β inhibitor with IC50 of 8 nM, weakly inhibits CDK1/cyclin B and CDK5/p25 (IC50=0.5 and 0.3 uM); stimulates INS-1E beta cell replication and protects INS-1E cells against glucolipotoxicity induced cell death, also stimulates the replication of primary beta cells in isolated rat islets.
In Vitro

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In Vivo

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Synonyms

9-Cyano-1-azapaullone
Pathway

PI3K/Akt/mTOR signaling
Target

GSK-3
Recptor

GSK-3
Research Area

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Indication

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CAS Number

914088-64-5
Formula Weight

274.283
Molecular Formula

C16H10N4O
Purity

>98% (HPLC)
Solubility

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SMILES

N#CC1=CC2=C(NC3=C2CC(NC4=CC=CN=C43)=O)C=C1
Chemical Name

6-Oxo-5,6,7,12-tetrahydropyrido(3',2'-2,3)azepino(4,5-b)indole-9-carbonitrile

1. Stukenbrock H, et al. J Med Chem. 2008 Apr 10;51(7):2196-207.

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