Cart
sales@molnova.com
Cazpaullone
CAS No. 914088-64-5
Cazpaullone( 9-Cyano-1-azapaullone )
Catalog No. M16568 CAS No. 914088-64-5
Cazpaullone (9-Cyano-1-azapaullone) is a derivative of 1-Azakenpaullone, a potent, selective GSK3β inhibitor with IC50 of 8 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameCazpaullone
-
NoteResearch use only, not for human use.
-
Brief DescriptionCazpaullone (9-Cyano-1-azapaullone) is a derivative of 1-Azakenpaullone, a potent, selective GSK3β inhibitor with IC50 of 8 nM.
-
DescriptionCazpaullone (9-Cyano-1-azapaullone) is a derivative of 1-Azakenpaullone, a potent, selective GSK3β inhibitor with IC50 of 8 nM, weakly inhibits CDK1/cyclin B and CDK5/p25 (IC50=0.5 and 0.3 uM); stimulates INS-1E beta cell replication and protects INS-1E cells against glucolipotoxicity induced cell death, also stimulates the replication of primary beta cells in isolated rat islets.
-
In Vitro——
-
In Vivo——
-
Synonyms9-Cyano-1-azapaullone
-
PathwayPI3K/Akt/mTOR signaling
-
TargetGSK-3
-
RecptorGSK-3
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number914088-64-5
-
Formula Weight274.283
-
Molecular FormulaC16H10N4O
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESN#CC1=CC2=C(NC3=C2CC(NC4=CC=CN=C43)=O)C=C1
-
Chemical Name6-Oxo-5,6,7,12-tetrahydropyrido(3',2'-2,3)azepino(4,5-b)indole-9-carbonitrile
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Stukenbrock H, et al. J Med Chem. 2008 Apr 10;51(7):2196-207.
molnova catalog
related products
-
AZD1080
AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor, inhibits human GSK3α and GSK3β with Ki of 6.9 nM and 31 nM, respectively.
-
GSK-3β inhibitor 1
GSK-3β inhibitor 1 is an inhibitor of GSK-3β( IC50 of 4.9 nM) and demonstrates high antidiabetic efficacy.GSK-3β inhibitor 1(compound 3a) inhibits GSK-3β with IC50 4.19 nM.?In a cell-based assay 3a shows no significant leucocyte toxicity at 10 M and is moderately cytotoxic against A549 cells.?
-
BRD0705
BRD0705 (BRD-0705) is a potent, paralog-selective GSK3α inhibitor with IC50 of 66 nM.
