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Home - Products - MAPK/ERK Signaling - Raf - GDC-0879

GDC-0879

CAS No. 905281-76-7

GDC-0879( GDC0879 | GDC 0879 )

Catalog No. M16507 CAS No. 905281-76-7

A potent and selective B-Raf kinase inhibitor with IC50 of 0.13 nM against purified B-Raf V600E and a cellular pERK IC50 of 63 nM in the MALME-3M cell line.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 75 In Stock
2MG 43 In Stock
5MG 68 In Stock
10MG 107 In Stock
25MG 217 In Stock
50MG 346 In Stock
100MG 555 In Stock
200MG 790 In Stock
500MG Get Quote In Stock
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Biological Information

  • Product Name
    GDC-0879
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent and selective B-Raf kinase inhibitor with IC50 of 0.13 nM against purified B-Raf V600E and a cellular pERK IC50 of 63 nM in the MALME-3M cell line.
  • Description
    A potent and selective B-Raf kinase inhibitor with IC50 of 0.13 nM against purified B-Raf V600E and a cellular pERK IC50 of 63 nM in the MALME-3M cell line; shows expected activity only against C-Raf against a panel of 140 kinases at 1 uM; shows comparable potency in A375 melanoma and Colo205 colorectal carcinoma cell lines with IC50 of 59 nM and 29 nM for pMEK1 inhibition respectively; shows tumor growth inhibition in A375 xenografts; orally active.Skin Cancer Preclinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    GDC0879 | GDC 0879
  • Pathway
    MAPK/ERK Signaling
  • Target
    Raf
  • Recptor
    B-Raf
  • Research Area
    Cancer
  • Indication
    Skin Cancer

Chemical Information

  • CAS Number
    905281-76-7
  • Formula Weight
    334.3718
  • Molecular Formula
    C19H18N4O2
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    OCCN1N=C(C2=CC=NC=C2)C(C3=CC4=C(/C(CC4)=N/O)C=C3)=C1
  • Chemical Name
    1H-Inden-1-one, 2,3-dihydro-5-[1-(2-hydroxyethyl)-3-(4-pyridinyl)-1H-pyrazol-4-yl]-, oxime

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wong H, et al. J Pharmacol Exp Ther. 2009 Apr;329(1):360-7. 2. Hoeflich KP, et al. Cancer Res. 2009 Apr 1;69(7):3042-51. 3. Hansen JD, et al. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4692-5.
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