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NXL101

CAS No. 904302-98-3

NXL101( NXL 101 )

Catalog No. M16502 CAS No. 904302-98-3

NXL101 is a novel quinoline bacterial DNA gyrase and topoisomerase IV inhibitor that shows potent activity against gram-positive bacteria.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    NXL101
  • Note
    Research use only, not for human use.
  • Brief Description
    NXL101 is a novel quinoline bacterial DNA gyrase and topoisomerase IV inhibitor that shows potent activity against gram-positive bacteria.
  • Description
    NXL101 is a novel quinoline bacterial DNA gyrase and topoisomerase IV inhibitor that shows potent activity against gram-positive bacteria, including methicillin- and fluoroquinolone-resistant strains; inhibits S. aureus DNA gyrase and topoisomerase IV with IC50 of 1.0 and 18 uM, respectively.Bacterial Infection Phase 1 Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    NXL 101
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    Antibacterial
  • Research Area
    Infection
  • Indication
    Bacterial Infection

Chemical Information

  • CAS Number
    904302-98-3
  • Formula Weight
    504.635
  • Molecular Formula
    C25H29FN2O4S2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C([C@H]1CN(CCSC2=CC=CS2)CC[C@H]1CC[C@@H](C3=C(F)C=NC4=CC=C(OC)C=C34)O)O
  • Chemical Name
    (3R,4R)-4-[(3S)-3-(3-Fluoro-6-methoxy-4-quinolinyl)-3-hydroxypropyl]-1-[2-(2-thienylthio)ethyl]-3-piperidinecarboxylic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Black MT, et al. Antimicrob Agents Chemother. 2008 Sep;52(9):3339-49.
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