Bicalutamide( ICI 176334 | ZD 176334 )

Catalog No. M16494 CAS No. 90357-06-5

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Datasheet

HNMR

HPLC

MSDS

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Product Name

Bicalutamide
Note

Research use only, not for human use.
Brief Description

Bicalutamide is an oral non-steroidal anti-androgen for prostate Y.
Description

Bicalutamide is an oral non-steroidal anti-androgen for prostate Y. It binds to the androgen receptor.
In Vitro

——
In Vivo

Animal Model:Castrate male mice, bearing LNCaP/AR(cs) xenograft tumors Dosage:10 mg/kg Administration:Oral gavage, daily, for 28 daysResult:Inhibited tumors growth.
Synonyms

ICI 176334 | ZD 176334
Pathway

Endocrinology/Hormones
Target

Androgen Receptor (AR)
Recptor

Androgen Receptor
Research Area

Cancer
Indication

——

CAS Number

90357-06-5
Formula Weight

430.37
Molecular Formula

C18H14F4N2O4S
Purity

>98% (HPLC)
Solubility

Ethanol: 5 mg/mL (11.61 mM); DMSO: 86 mg/mL (199.82 mM)
SMILES

O=C(NC1=CC=C(C#N)C(C(F)(F)F)=C1)C(C)(O)CS(=O)(C2=CC=C(F)C=C2)=O
Chemical Name

N-(4-cyano-3-(trifluoromethyl)phenyl)-3-((4-fluorophenyl)sulfonyl)-2-hydroxy-2-methylpropanamide

1. Wang LG, et al. Biochem Pharmacol. 1998 May 1; 55(9):1427-33.

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